Zfp36l1 establishes the high‐affinity CD8 T‐cell response by directly linking TCR affinity to cytokine sensing
Abstract: How individual T cells compete for and respond to IL‐2 at the molecular level, and, as a consequence, how this shapes population dynamics and the selection of high‐affinity clones is still poorly understood. Here we describe how the RNA binding protein ZFP36L1, acts as a sensor of TCR affinity to promote clonal expansion of high‐affinity CD8 T cells. As part of an incoherent feed‐forward loop, ZFP36L1 has a nonredundant role in suppressing multiple negative regulators of cytokine signaling and mediating a selection mechanism based on competition for IL‐2. We suggest that ZFP36L1 acts as a sensor of antigen affinity and establishes the dominance of high‐affinity T cells by installing a hierarchical response to IL‐2.
- Location
-
Deutsche Nationalbibliothek Frankfurt am Main
- Extent
-
Online-Ressource
- Language
-
Englisch
- Bibliographic citation
-
Zfp36l1 establishes the high‐affinity CD8 T‐cell response by directly linking TCR affinity to cytokine sensing ; day:07 ; month:12 ; year:2023 ; extent:16
European journal of immunology ; (07.12.2023) (gesamt 16)
- Creator
-
Petkau, Georg
Mitchell, Twm J.
Evans, Marian Jones
Matheson, Louise
Salerno, Fiamma
Turner, Martin
- DOI
-
10.1002/eji.202350700
- URN
-
urn:nbn:de:101:1-2023120815133108297346
- Rights
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
-
15.08.2025, 7:20 AM CEST
Data provider
This object is provided by:
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Petkau, Georg
- Mitchell, Twm J.
- Evans, Marian Jones
- Matheson, Louise
- Salerno, Fiamma
- Turner, Martin
Other Objects (12)
High-affinity biomolecular interactions are modulated by low-affinity binders
Chronic TCR-MHC (self)-interactions limit the functional potential of TCR affinity-increased CD8 T lymphocytes
Design of a high-affinity carbohydrate binding protein
A High‐Affinity “Synthavidin” Receptor for Squaraine Dyes
A High‐Affinity “Synthavidin” Receptor for Squaraine Dyes
Rapid discovery of high-affinity antibodies via massively parallel sequencing, ribosome display and affinity screening
High-affinity antiviral CAR-T cells against HCMV-reactivation
High-affinity ammonium transport by Arabidopsis thaliana AMT1;4
High‐Affinity Hybridization of Complementary Aromatic Oligoamide Strands in Water
X-ray structures of the high-affinity copper transporter Ctr1
High‐Affinity Hybridization of Complementary Aromatic Oligoamide Strands in Water
Precipitation-free high-affinity multivalent binding by inline lectin ligands
High-affinity biomolecular interactions are modulated by low-affinity binders
Chronic TCR-MHC (self)-interactions limit the functional potential of TCR affinity-increased CD8 T lymphocytes
Design of a high-affinity carbohydrate binding protein
A High‐Affinity “Synthavidin” Receptor for Squaraine Dyes
A High‐Affinity “Synthavidin” Receptor for Squaraine Dyes
Rapid discovery of high-affinity antibodies via massively parallel sequencing, ribosome display and affinity screening
High-affinity antiviral CAR-T cells against HCMV-reactivation
High-affinity ammonium transport by Arabidopsis thaliana AMT1;4
High‐Affinity Hybridization of Complementary Aromatic Oligoamide Strands in Water
X-ray structures of the high-affinity copper transporter Ctr1
High‐Affinity Hybridization of Complementary Aromatic Oligoamide Strands in Water
Precipitation-free high-affinity multivalent binding by inline lectin ligands
High-affinity biomolecular interactions are modulated by low-affinity binders
Chronic TCR-MHC (self)-interactions limit the functional potential of TCR affinity-increased CD8 T lymphocytes
Design of a high-affinity carbohydrate binding protein
A High‐Affinity “Synthavidin” Receptor for Squaraine Dyes
A High‐Affinity “Synthavidin” Receptor for Squaraine Dyes
Rapid discovery of high-affinity antibodies via massively parallel sequencing, ribosome display and affinity screening
High-affinity antiviral CAR-T cells against HCMV-reactivation
High-affinity ammonium transport by Arabidopsis thaliana AMT1;4
High‐Affinity Hybridization of Complementary Aromatic Oligoamide Strands in Water
X-ray structures of the high-affinity copper transporter Ctr1
High‐Affinity Hybridization of Complementary Aromatic Oligoamide Strands in Water