High‐Affinity Hybridization of Complementary Aromatic Oligoamide Strands in Water
Abstract: We prepared a series of water‐soluble aromatic oligoamide sequences all composed of a segment prone to form a single helix and a segment prone to dimerize into a double helix. These sequences exclusively assemble as antiparallel duplexes. The modification of the duplex inner rim by varying the nature of the substituents borne by the aromatic monomers allowed us to identify sequences that can hybridize by combining two chemically different strands, with high affinity and complete selectivity in water. X‐ray crystallography confirmed the expected antiparallel configuration of the duplexes whereas NMR spectroscopy and mass spectrometry allowed us to assess precisely the extent of the hybridization. The hybridization kinetics of the aromatic strands was shown to depend on both the nature of the substituents responsible for strand complementarity and the length of the aromatic strand. These results highlight the great potential of aromatic hetero‐duplex as a tool to construct non‐symmetrical dynamic supramolecular assemblies.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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High‐Affinity Hybridization of Complementary Aromatic Oligoamide Strands in Water ; day:23 ; month:10 ; year:2023 ; extent:6
Angewandte Chemie ; (23.10.2023) (gesamt 6)
- Creator
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Koehler, Victor
Bruschera, Gabrielle
Merlet, Eric
Mandal, Pradeep K.
Morvan, Estelle
Rosu, Frédéric
Douat, Céline
Fischer, Lucile
Huc, Ivan
Ferrand, Yann
- DOI
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10.1002/ange.202311639
- URN
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urn:nbn:de:101:1-2023102315340731427586
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 11:02 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Koehler, Victor
- Bruschera, Gabrielle
- Merlet, Eric
- Mandal, Pradeep K.
- Morvan, Estelle
- Rosu, Frédéric
- Douat, Céline
- Fischer, Lucile
- Huc, Ivan
- Ferrand, Yann
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Design of a high-affinity carbohydrate binding protein
A High‐Affinity “Synthavidin” Receptor for Squaraine Dyes
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