Zfp36l1 establishes the high‐affinity CD8 T‐cell response by directly linking TCR affinity to cytokine sensing
Abstract: How individual T cells compete for and respond to IL‐2 at the molecular level, and, as a consequence, how this shapes population dynamics and the selection of high‐affinity clones is still poorly understood. Here we describe how the RNA binding protein ZFP36L1, acts as a sensor of TCR affinity to promote clonal expansion of high‐affinity CD8 T cells. As part of an incoherent feed‐forward loop, ZFP36L1 has a nonredundant role in suppressing multiple negative regulators of cytokine signaling and mediating a selection mechanism based on competition for IL‐2. We suggest that ZFP36L1 acts as a sensor of antigen affinity and establishes the dominance of high‐affinity T cells by installing a hierarchical response to IL‐2.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Zfp36l1 establishes the high‐affinity CD8 T‐cell response by directly linking TCR affinity to cytokine sensing ; day:07 ; month:12 ; year:2023 ; extent:16
European journal of immunology ; (07.12.2023) (gesamt 16)
- Urheber
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Petkau, Georg
Mitchell, Twm J.
Evans, Marian Jones
Matheson, Louise
Salerno, Fiamma
Turner, Martin
- DOI
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10.1002/eji.202350700
- URN
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urn:nbn:de:101:1-2023120815133108297346
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:20 MESZ
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Beteiligte
- Petkau, Georg
- Mitchell, Twm J.
- Evans, Marian Jones
- Matheson, Louise
- Salerno, Fiamma
- Turner, Martin
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