Flavin‐Dependent Nitroreductases: Privileged Enzymes for Chemical and Photochemical Synthesis
Abstract: Nitroreductases, present within both prokaryotes and eukaryotes, form a group of flavin‐dependent enzymes capable of reducing nitro compounds using NAD (P) H as reducing agent. These enzymes have been widely studied due to their diverse roles in bioremediation, cancer therapy, cell ablation, and antimicrobial resistance. In recent times, the versatility of nitroreductases has been expanded toward the synthesis of highly valuable compounds such as aromatic and aliphatic amines, azoxy and azobenzenes, as well as N‐heterocycles. This review examines the biological role and diversity of flavin‐dependent nitroreductases, and highlights their current and potential future application as biocatalysts for the sustainable synthesis of nitrogen‐containing pharmaceutical compounds and bulk chemicals.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Flavin‐Dependent Nitroreductases: Privileged Enzymes for Chemical and Photochemical Synthesis ; day:27 ; month:12 ; year:2024 ; extent:19
ChemCatChem ; (27.12.2024) (gesamt 19)
- Creator
- DOI
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10.1002/cctc.202401304
- URN
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urn:nbn:de:101:1-2412281312357.061400906681
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:27 AM CEST
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Associated
- Russo, Sara
- Luján, Alejandro Prats
- Fraaije, Marco W.
- Poelarends, Gerrit
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Flavin‐Catalyzed, Photochemical Conversion of Dehydroalanine into 4,5‐Dihydroxynorvaline
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Flavin-dependent N-hydroxylating enzymes: distribution and application
Preparation and some properties of 6-substituted flavins as active site probes for flavin enzymes
Hydroxylation by flavin enzymes : evidence for NIH-shift mechanism
Privileged disloyalty
Structure and mechanism of several flavin-based electron bifurcating enzymes
Privileged Structures Revisited
New flavins and their application to chemical photocatalysis
Enhancing Flavins Photochemical Activity in Hydrogen Atom Abstraction and Triplet Sensitization through Ring‐Contraction
Photochemical Desaturation and Epoxidation with Oxygen by Sequential Flavin Catalysis
Photochemical Desaturation and Epoxidation with Oxygen by Sequential Flavin Catalysis
Flavin‐Catalyzed, Photochemical Conversion of Dehydroalanine into 4,5‐Dihydroxynorvaline
Flavin‐Catalyzed, Photochemical Conversion of Dehydroalanine into 4,5‐Dihydroxynorvaline
Flavin-dependent N-hydroxylating enzymes: distribution and application
Preparation and some properties of 6-substituted flavins as active site probes for flavin enzymes
Hydroxylation by flavin enzymes : evidence for NIH-shift mechanism
Privileged disloyalty
Structure and mechanism of several flavin-based electron bifurcating enzymes
Privileged Structures Revisited
New flavins and their application to chemical photocatalysis