Flavin‐Dependent Nitroreductases: Privileged Enzymes for Chemical and Photochemical Synthesis
Abstract: Nitroreductases, present within both prokaryotes and eukaryotes, form a group of flavin‐dependent enzymes capable of reducing nitro compounds using NAD (P) H as reducing agent. These enzymes have been widely studied due to their diverse roles in bioremediation, cancer therapy, cell ablation, and antimicrobial resistance. In recent times, the versatility of nitroreductases has been expanded toward the synthesis of highly valuable compounds such as aromatic and aliphatic amines, azoxy and azobenzenes, as well as N‐heterocycles. This review examines the biological role and diversity of flavin‐dependent nitroreductases, and highlights their current and potential future application as biocatalysts for the sustainable synthesis of nitrogen‐containing pharmaceutical compounds and bulk chemicals.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Flavin‐Dependent Nitroreductases: Privileged Enzymes for Chemical and Photochemical Synthesis ; day:27 ; month:12 ; year:2024 ; extent:19
ChemCatChem ; (27.12.2024) (gesamt 19)
- Urheber
- DOI
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10.1002/cctc.202401304
- URN
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urn:nbn:de:101:1-2412281312357.061400906681
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:27 MESZ
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Beteiligte
- Russo, Sara
- Luján, Alejandro Prats
- Fraaije, Marco W.
- Poelarends, Gerrit
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Structure and mechanism of several flavin-based electron bifurcating enzymes
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