Formation and characterisation of hydrogel diffusion channels for directed drug delivery

Abstract: Drug Delivery Systems (DDS) are frequently operating in a surrounding liquid environment, such as blood in the case of drug-eluting stents or perilymph in the case of cochlear implants. However, there is also a demand for systems with sustained drug release in predominantly dry environments, mostly consisting of ambient air. Examples are the treatment of diseases located in the middle ear or the paranasal sinuses. On the one hand, due to the lack of transportation media, the functionality of a polymer/drug combination for delayed release would be limited in such environments. On the other hand, these environments are generally equipped with mucus membranes. Hence, a somewhat humid surrounding is ensured. In this study, a concept of a hydrogel equipped DDS for drug delivery through the round window membrane is presented, addressing two objectives. First objective is to ensure the drug transport by serving as a diffusion channel. For instance the route to the drug target destination, the round window membrane, can be provided by a hydrogel. The second objective is to ensure the adhesion to the membrane. Two promising approaches are presented in this study: The photo induced immobilisation of PEGDA700, as well as the immobilisation of chitosan on poly (l-lactid) (PLLA). For both approaches PLLA specimen had to be modified with oxygen plasma followed by activation for crosslinking with subsequent immobilisation of the hydrogel. With these methods a layer thickness of at least 5 μm was achieved. All steps were characterized with contact angle measurements. After the immobilization of the hydrogel, the swelling factor, as well as the layer thickness was examined.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Formation and characterisation of hydrogel diffusion channels for directed drug delivery ; volume:5 ; number:1 ; year:2019 ; pages:323-325 ; extent:4 ; Current directions in biomedical engineering ; 5, Heft 1 (2019), 323-325 (gesamt 4)

Contributors, Places and Time

• Creator: Eickner, Thomas ; Kohse, Stefanie ; Illner, Sabine ; Oschatz, Stefan ; Teske, Michael ; Rekowska, Natalia ; Senz, Volkmar ; Schmitz, Klaus-Peter ; Grabow, Niels

Further information

• DOI: 10.1515/cdbme-2019-0081
• URN: urn:nbn:de:101:1-2022101214535077809324
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:22 AM CEST