Cell adhesion and viability of human endothelial cells on electrospun polymer scaffolds
Abstract: The usage of electrospun polymer scaffolds is a promising approach for artificial heart valve design. This study aims at the evaluation of biological performance of nanofibrous polymer scaffolds poly (L-lactide) PLLA L210, PLLA L214 and polyamide-6 fabricated by electrospinning via analyzing viability, adhesion and morphology of human umbilical vein endothelial cells (EA.hy926). Nanofibrous surface topography was shown to influence cell phenotype and cell viability according to the observation of diminished cell spreading accompanied with reduced cell viability on nonwovens. Among those, highest biocompatibility was assessed for PLLA L214, although being generally low when compared to the planar control surface. Electrospinning was demonstrated as an innovative technique for the fabrication of advanced biomaterials aiming at guided cellular behavior as well as the design of novel implant platforms. A better understanding of cell–biomaterial interactions is desired to further improve implant development.
- Standort
-
Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
-
Online-Ressource
- Sprache
-
Englisch
- Erschienen in
-
Cell adhesion and viability of human endothelial cells on electrospun polymer scaffolds ; volume:2 ; number:1 ; year:2016 ; pages:11-14 ; extent:4
Current directions in biomedical engineering ; 2, Heft 1 (2016), 11-14 (gesamt 4)
- Urheber
-
Matschegewski, Claudia
Matthies, Jörn-Bo
Grabow, Niels
Schmitz, Klaus-Peter
- DOI
-
10.1515/cdbme-2016-0006
- URN
-
urn:nbn:de:101:1-2410141640092.946861844480
- Rechteinformation
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
-
26.04.2024, 05:35 MESZ
Datenpartner
Dieses Objekt wird bereitgestellt von:
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Matschegewski, Claudia
- Matthies, Jörn-Bo
- Grabow, Niels
- Schmitz, Klaus-Peter
Ähnliche Objekte (12)
Reconstruction of biological functions: novel implant concepts for cardiovascular, ophthal-mologic and otolaryngologic applications : Current research and development activities of the Twenty20 consortium RESPONSE
Transfer activities for cardiovascular, ophthalmologic and otolaryngologic medical device innovations
Medical device innovations for cardiovascular, ophthalmologic and otolaryngologic applications : Progress report from the Twenty20 consortium RESPONSE
Cardiovascular, ophthalmologic and otolaryngologic medical device innovations – Progress report 2021 from the Twenty20 consortium RESPONSE
Electrospinning of polyimide nanofibres – effects of working parameters on morphology
Conversion of engineering stresses to Cauchy stresses in tensile and compression tests of thermoplastic polymers
Transient Euler-Lagrange/DEM simulation of stent thrombosis
Method for the improvement of mechanical properties of biodegradable polymeric scaffolds
Degradable dual co-electrospun polyester based nonwovens for guided tissue regeneration
Fabrication of polymer-based stents: Impact of test specimen manufacturing protocol
Investigation of Bauschinger effect in thermo-plastic polymers for biodegradable stents
Numerical simulation of pulsatile flow through a coronary nozzle model based on FDA’s benchmark geometry
Reconstruction of biological functions: novel implant concepts for cardiovascular, ophthal-mologic and otolaryngologic applications : Current research and development activities of the Twenty20 consortium RESPONSE
Transfer activities for cardiovascular, ophthalmologic and otolaryngologic medical device innovations
Medical device innovations for cardiovascular, ophthalmologic and otolaryngologic applications : Progress report from the Twenty20 consortium RESPONSE
Cardiovascular, ophthalmologic and otolaryngologic medical device innovations – Progress report 2021 from the Twenty20 consortium RESPONSE
Electrospinning of polyimide nanofibres – effects of working parameters on morphology
Conversion of engineering stresses to Cauchy stresses in tensile and compression tests of thermoplastic polymers
Transient Euler-Lagrange/DEM simulation of stent thrombosis
Method for the improvement of mechanical properties of biodegradable polymeric scaffolds
Degradable dual co-electrospun polyester based nonwovens for guided tissue regeneration
Fabrication of polymer-based stents: Impact of test specimen manufacturing protocol
Investigation of Bauschinger effect in thermo-plastic polymers for biodegradable stents
Numerical simulation of pulsatile flow through a coronary nozzle model based on FDA’s benchmark geometry
Reconstruction of biological functions: novel implant concepts for cardiovascular, ophthal-mologic and otolaryngologic applications : Current research and development activities of the Twenty20 consortium RESPONSE
Transfer activities for cardiovascular, ophthalmologic and otolaryngologic medical device innovations
Medical device innovations for cardiovascular, ophthalmologic and otolaryngologic applications : Progress report from the Twenty20 consortium RESPONSE
Cardiovascular, ophthalmologic and otolaryngologic medical device innovations – Progress report 2021 from the Twenty20 consortium RESPONSE
Electrospinning of polyimide nanofibres – effects of working parameters on morphology
Conversion of engineering stresses to Cauchy stresses in tensile and compression tests of thermoplastic polymers
Transient Euler-Lagrange/DEM simulation of stent thrombosis
Method for the improvement of mechanical properties of biodegradable polymeric scaffolds
Degradable dual co-electrospun polyester based nonwovens for guided tissue regeneration
Fabrication of polymer-based stents: Impact of test specimen manufacturing protocol
Investigation of Bauschinger effect in thermo-plastic polymers for biodegradable stents