The role of natural killer cells and CD8+ T cells in hepatitis b virus infection
Abstract: Hepatitis B virus (HBV) infection is one of the main causes of chronic liver diseases that may progress to liver cirrhosis and hepatocellular carcinoma. Host immune responses are important factors that determine whether HBV infection is cleared or persists. Natural killer (NK) cells represent the main effector population of the innate immune system and are abundant in the human liver. Recently, it has been demonstrated that NK cells not only exhibit antiviral functions but may also regulate adaptive immune responses by deletion of HBV-specific CD8+ T cells. It is well-established that HBV-specific CD8+ T cells contribute to virus elimination. However, the mechanisms contributing to CD8+ T cell failure in chronic HBV infection are not well-understood. In this review, we will summarize the current knowledge about NK cells and CD8+ T cells and illustrate their contribution to viral clearance and persistence in HBV infection. Moreover, novel immunological in vitro model systems and techniques to analyze HBV-specific CD8+ T cells, which are barely detectable using current multimer staining methods, will be discussed.
Introduction
- Location
-
Deutsche Nationalbibliothek Frankfurt am Main
- Extent
-
Online-Ressource
- Language
-
Englisch
- Notes
-
Frontiers in immunology. - 5 (2014) , 00258, ISSN: 1664-3224
- Event
-
Veröffentlichung
- (where)
-
Freiburg
- (who)
-
Universität
- (when)
-
2019
- DOI
-
10.3389/fimmu.2014.00258
- URN
-
urn:nbn:de:bsz:25-freidok-1202795
- Rights
-
Kein Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
-
25.03.2025, 1:45 PM CET
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Schuch, Anita
- Hoh, Alexander
- Thimme, Robert
- Universität
Time of origin
- 2019
Other Objects (12)
CD8+ T cell responses during HCV infection and HCC
Heterogeneity of HBV-specific CD8+ T cells and CD56 dim NK cells and their impact on immune failure in chronic HBV infection
Success and failure of virus-specific T Cell responses in Hepatitis C virus infection
T cell immunity to hepatitis C virus: Lessons for a prophylactic vaccine
A liver immune rheostat regulates CD8 T cell immunity in chronic HBV infection
Heterogeneity of HBV-specific CD8+ T-cell failure: implications for immunotherapy
CD8-T-Zell-Differenzierung bei Patienten mit Common Variable Immunodeficiency
Tumorantigen-spezifische CD8+ T-Zellen bei Patienten mit hepatozellulaerem Karzinom
HCV-specific T cell responses during and after chronic HCV infection
Hepatitis B vaccine and NK cells: a new player in memory
Immunopathology caused by impaired CD8+ T‐cell responses
Chronische Hepatitis-B-Virusinfektion: aktuelle und zukünftige Therapieansätze : = Chronic hepatitis B virus infection: current and future treatment strategies
CD8+ T cell responses during HCV infection and HCC
Heterogeneity of HBV-specific CD8+ T cells and CD56 dim NK cells and their impact on immune failure in chronic HBV infection
Success and failure of virus-specific T Cell responses in Hepatitis C virus infection
T cell immunity to hepatitis C virus: Lessons for a prophylactic vaccine
A liver immune rheostat regulates CD8 T cell immunity in chronic HBV infection
Heterogeneity of HBV-specific CD8+ T-cell failure: implications for immunotherapy
CD8-T-Zell-Differenzierung bei Patienten mit Common Variable Immunodeficiency
Tumorantigen-spezifische CD8+ T-Zellen bei Patienten mit hepatozellulaerem Karzinom
HCV-specific T cell responses during and after chronic HCV infection
Hepatitis B vaccine and NK cells: a new player in memory
Immunopathology caused by impaired CD8+ T‐cell responses
Chronische Hepatitis-B-Virusinfektion: aktuelle und zukünftige Therapieansätze : = Chronic hepatitis B virus infection: current and future treatment strategies
CD8+ T cell responses during HCV infection and HCC
Heterogeneity of HBV-specific CD8+ T cells and CD56 dim NK cells and their impact on immune failure in chronic HBV infection
Success and failure of virus-specific T Cell responses in Hepatitis C virus infection
T cell immunity to hepatitis C virus: Lessons for a prophylactic vaccine
A liver immune rheostat regulates CD8 T cell immunity in chronic HBV infection
Heterogeneity of HBV-specific CD8+ T-cell failure: implications for immunotherapy
CD8-T-Zell-Differenzierung bei Patienten mit Common Variable Immunodeficiency
Tumorantigen-spezifische CD8+ T-Zellen bei Patienten mit hepatozellulaerem Karzinom
HCV-specific T cell responses during and after chronic HCV infection
Hepatitis B vaccine and NK cells: a new player in memory
Immunopathology caused by impaired CD8+ T‐cell responses