Hochschulschrift
CD8-T-Zell-Differenzierung bei Patienten mit Common Variable Immunodeficiency
Zusammenfassung: Common variable immunodeficiency (CVID) is a heterogeneous antibody deficiency syndrome with alterations in T cell regulation and function in a subgroup of patients. Phenotype and function of bulk and virus-specific CD8+ T cells of a cohort of 34 HLA-A2+ CVID patients were assessed by pentamer technology and flow cytometry in relationship to their immunological and clinical phenotypes. Bulk CD8+ T cells displayed a shift toward a more antigen experienced and activated differentiation state. The advanced differentiation pattern was mainly found in a subgroup of CVID patients with lymphadenopathy and granulomatous disease. This effect existed independently of the patients' CMV status, even so CMV-associated immunosenescence was more evident in CVID patients than in CMV-positive immunocompetent controls. CMV-, EBV-, and Influenza-virus-specific CD8+ T cells of CVID patients displayed a regular differentiation pattern when compared to controls and appeared to be functional in terms of interferon gamma production
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Deutsch
- Anmerkungen
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Albert-Ludwigs-Universität Freiburg, Dissertation, 2011
- Schlagwort
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Antigen CD8
T-Lymphozyt
Primärer Immundefekt
Immunreaktion
Epstein-Barr-Virus
Cytomegalie-Virus
Influenza-A-Virus
Lymphadenopathie
Online-Ressource
- Ereignis
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Veröffentlichung
- (wo)
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Freiburg
- (wer)
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Universität
- (wann)
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2011
- Urheber
- Beteiligte Personen und Organisationen
- URN
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urn:nbn:de:bsz:25-opus-84129
- Rechteinformation
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Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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14.08.2025, 10:49 MESZ
Datenpartner
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Objekttyp
- Hochschulschrift
Beteiligte
- Kuntz, Martin
- Thimme, Robert
- Universität
Entstanden
- 2011
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