A General Acid‐Mediated Hydroaminomethylation of Unactivated Alkenes and Alkynes

Abstract: In comparison to the extensively studied metal‐catalyzed hydroamination reaction, hydroaminomethylation has received significantly less attention despite its considerable potential to streamline amine synthesis. State‐of‐the‐art protocols for hydroaminomethylation of alkenes rely largely on transition‐metal catalysis, enabling this transformation only under highly designed and controlled conditions. Here we report a broadly applicable, acid‐mediated approach to the hydroaminomethylation of unactivated alkenes and alkynes. This methodology employs cheap, readily available, and bench‐stable reactants and affords the desired amines with excellent functional group tolerance and impeccable regioselectivity. The broad scope of this transformation, as well as mechanistic investigations and in situ domino functionalization reactions are reported.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: A General Acid‐Mediated Hydroaminomethylation of Unactivated Alkenes and Alkynes ; volume:58 ; number:41 ; year:2019 ; pages:14639-14643 ; extent:5 ; Angewandte Chemie / International edition. International edition ; 58, Heft 41 (2019), 14639-14643 (gesamt 5)

Contributors, Places and Time

• Creator: Kaiser, Daniel ; Tona, Veronica ; Gonçalves, Carlos R. ; Shaaban, Saad ; Oppedisano, Alberto ; Maulide, Nuno

Further information

• DOI: 10.1002/anie.201906910
• URN: urn:nbn:de:101:1-2022070712364605333107
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:30 AM CEST