Radical‐Mediated Hydroperfluoroalkylation of Unactivated Alkenes

Abstract: The direct hydroperfluoroalkylation of a wide range of unactivated alkenes has been achieved at room temperature with readily available iodoperfluoroalkanes using 4‐tert‐butylcatechol as a source of hydrogen atom and triethylborane. The hydrotrifluoromethylation could also be achieved under these conditions using gaseous trifluoromethyl iodide. An experimentally simple two‐step, one‐pot hydrotrifluoromethylation process using the easy‐to‐use trifluoromethanesulfonyl chloride as the source of trifluoromethyl radicals has also been developed. Using these two approaches, a broad range of substrates, including isoprenoid natural products, were efficiently derivatized.

Angaben zum Objekt

• Standort: Deutsche Nationalbibliothek Frankfurt am Main
• Umfang: Online-Ressource
• Sprache: Englisch

Verweise und Beziehungen

• Erschienen in: Radical‐Mediated Hydroperfluoroalkylation of Unactivated Alkenes ; day:17 ; month:07 ; year:2023 ; extent:10 ; Advanced synthesis & catalysis ; (17.07.2023) (gesamt 10)

Beteiligte, Orts- und Zeitangaben

• Urheber: Sissengaliyeva, Gulsana ; Dénès, Fabrice ; Girbu, Vladilena ; Kulcitki, Veaceslav ; Hofstetter, Elena ; Renaud, Philippe

Weitere Informationen

• DOI: 10.1002/adsc.202300299
• URN: urn:nbn:de:101:1-2023071715213976935456
• Rechteinformation: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Letzte Aktualisierung: 14.08.2025, 10:02 MESZ