Autophagy in kidney disease and aging : : lessons from rodent models

Abstract: Autophagy is a highly regulated lysosomal protein degradation pathway that removes protein aggregates and damaged or excess organelles to maintain intracellular homeostasis and cell integrity. Dysregulation of autophagy is involved in the pathogenesis of a variety of metabolic and age-related diseases. Growing evidence suggests that autophagy is implicated in cell injury during renal diseases, both in the tubulointerstitial compartment and in glomeruli. Nevertheless, the impact of autophagy on renal disease progression and aging is still not fully understood. This review summarizes the recent advances in understanding the role of autophagy for kidney disease and aging

Location
Deutsche Nationalbibliothek Frankfurt am Main
Extent
Online-Ressource
Language
Englisch
Notes
Kidney international. - 90, 5 (2016) , 950-964, ISSN: 0085-2538

Event
Veröffentlichung
(where)
Freiburg
(who)
Universität
(when)
2025
Creator
Lenoir, Olivia
Tharaux, Pierre-Louis
Huber, Tobias
Contributor
FRIAS Natur- und Lebenswissenschaften, Medizin und Ingenieurwissenschaften

DOI
10.1016/j.kint.2016.04.014
URN
urn:nbn:de:bsz:25-freidok-1321294
Rights
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
Last update
15.08.2025, 7:30 AM CEST

Data provider

This object is provided by:
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Associated

  • Lenoir, Olivia
  • Tharaux, Pierre-Louis
  • Huber, Tobias
  • FRIAS Natur- und Lebenswissenschaften, Medizin und Ingenieurwissenschaften
  • Universität

Time of origin

  • 2025

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