Autophagy in kidney disease and aging : : lessons from rodent models
Abstract: Autophagy is a highly regulated lysosomal protein degradation pathway that removes protein aggregates and damaged or excess organelles to maintain intracellular homeostasis and cell integrity. Dysregulation of autophagy is involved in the pathogenesis of a variety of metabolic and age-related diseases. Growing evidence suggests that autophagy is implicated in cell injury during renal diseases, both in the tubulointerstitial compartment and in glomeruli. Nevertheless, the impact of autophagy on renal disease progression and aging is still not fully understood. This review summarizes the recent advances in understanding the role of autophagy for kidney disease and aging
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Notes
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Kidney international. - 90, 5 (2016) , 950-964, ISSN: 0085-2538
- Event
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Veröffentlichung
- (where)
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Freiburg
- (who)
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Universität
- (when)
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2025
- Creator
- Contributor
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FRIAS Natur- und Lebenswissenschaften, Medizin und Ingenieurwissenschaften
- DOI
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10.1016/j.kint.2016.04.014
- URN
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urn:nbn:de:bsz:25-freidok-1321294
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:30 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Lenoir, Olivia
- Tharaux, Pierre-Louis
- Huber, Tobias
- FRIAS Natur- und Lebenswissenschaften, Medizin und Ingenieurwissenschaften
- Universität
Time of origin
- 2025