Oak‐Associated Negativicute Equipped with Ancestral Aromatic Polyketide Synthase Produces Antimycobacterial Dendrubins
Abstract: Anaerobic bacteria have only recently been recognized as a source of antibiotics; yet, the metabolic potential of Negativicutes (Gram‐negative staining Firmicutes) such as the oak‐associated Dendrosporobacter quercicolus has remained unknown. Genome mining of D. quercicolus and phylogenetic analyses revealed a gene cluster for a type II polyketide synthase (PKS) complex that belongs to the most ancestral enzyme systems of this type. Metabolic profiling, NMR analyses, and stable‐isotope labeling led to the discovery of a new family of anthraquinone‐type polyphenols, the dendrubins, which are diversified by acylation, methylation, and dimerization. Dendrubin A and B were identified as strong antibiotics against a range of clinically relevant, human‐pathogenic mycobacteria.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Oak‐Associated Negativicute Equipped with Ancestral Aromatic Polyketide Synthase Produces Antimycobacterial Dendrubins ; volume:26 ; number:58 ; year:2020 ; pages:13147-13151 ; extent:5
Chemistry - a European journal ; 26, Heft 58 (2020), 13147-13151 (gesamt 5)
- Creator
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Ishida, Keishi
Shabuer, Gulimila
Schieferdecker, Sebastian
Pidot, Sacha J.
Stinear, Timothy P.
Knuepfer, Uwe
Cyrulies, Michael
Hertweck, Christian
- DOI
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10.1002/chem.202001939
- URN
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urn:nbn:de:101:1-2022060712592835846537
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:22 AM CEST
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Associated
- Ishida, Keishi
- Shabuer, Gulimila
- Schieferdecker, Sebastian
- Pidot, Sacha J.
- Stinear, Timothy P.
- Knuepfer, Uwe
- Cyrulies, Michael
- Hertweck, Christian
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