Novel Biocatalysts from Specialized Metabolism
Abstract: Enzymes are increasingly recognized as valuable (bio) catalysts that complement existing synthetic methods. However, the range of biotransformations used in the laboratory is limited. Here we give an overview on the biosynthesis‐inspired discovery of novel biocatalysts that address various synthetic challenges. Prominent examples from this dynamic field highlight remarkable enzymes for protecting‐group‐free amide formation and modification, control of pericyclic reactions, stereoselective hetero‐ and polycyclizations, atroposelective aryl couplings, site‐selective C−H activations, introduction of ring strain, and N−N bond formation. We also explore unusual functions of cytochrome P450 monooxygenases, radical SAM‐dependent enzymes, flavoproteins, and enzymes recruited from primary metabolism, which offer opportunities for synthetic biology, enzyme engineering, directed evolution, and catalyst design.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Novel Biocatalysts from Specialized Metabolism ; day:25 ; month:10 ; year:2023 ; extent:15
Angewandte Chemie ; (25.10.2023) (gesamt 15)
- DOI
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10.1002/ange.202309284
- URN
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urn:nbn:de:101:1-2023102515400489456368
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 10:49 AM CEST
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Associated
Other Objects (12)
Novel Biocatalysts from Specialized Metabolism
Novel Biocatalysts from Specialized Metabolism
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Novel Biocatalysts from Specialized Metabolism
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Funktionalisierte Vinyloxirane durch reduktive Allylierung von Estern : stereoselektive Synthesen von Lamoxiren und Sphingoidbasen
Investigation of the specialized metabolism of Clostridium spp. reveals novel biosynthetic assemblies and a self-resistance mechanism
Photosensitizers Enable the Formation of Biphenyls with UV‐LEDs and Sunlight
Deciphering Chemical Mediators Regulating Specialized Metabolism in a Symbiotic Cyanobacterium
Loss of Single‐Domain Function in a Modular Assembly Line Alters the Size and Shape of a Complex Polyketide
A Photochemical Macrocyclization Route to Asymmetric Strained (3.2) Paracyclophanes
A Type III Polyketide Synthase Specific for Sporulating Negativicutes is Responsible for Alkylpyrone Biosynthesis
Bacterial Isothiocyanate Biosynthesis by Rhodanese‐Catalyzed Sulfur Transfer onto Isonitriles
Thiotemplated Biosynthesis of Bacterial Polyyne Fatty Acids by a Designated Desaturase Triad
Profilometry of plant surfaces to facilitate consistent, in vivo laser ablation electrospray ionization of specialized metabolites
Novel Biocatalysts from Specialized Metabolism
Novel Biocatalysts from Specialized Metabolism
Funktionalisierte Vinyloxirane durch reduktive Allylierung von Estern : stereoselektive Synthesen von Lamoxiren und Sphingoidbasen
Investigation of the specialized metabolism of Clostridium spp. reveals novel biosynthetic assemblies and a self-resistance mechanism
Photosensitizers Enable the Formation of Biphenyls with UV‐LEDs and Sunlight
Deciphering Chemical Mediators Regulating Specialized Metabolism in a Symbiotic Cyanobacterium
Loss of Single‐Domain Function in a Modular Assembly Line Alters the Size and Shape of a Complex Polyketide
A Photochemical Macrocyclization Route to Asymmetric Strained (3.2) Paracyclophanes
A Type III Polyketide Synthase Specific for Sporulating Negativicutes is Responsible for Alkylpyrone Biosynthesis
Bacterial Isothiocyanate Biosynthesis by Rhodanese‐Catalyzed Sulfur Transfer onto Isonitriles
Thiotemplated Biosynthesis of Bacterial Polyyne Fatty Acids by a Designated Desaturase Triad