Oak‐Associated Negativicute Equipped with Ancestral Aromatic Polyketide Synthase Produces Antimycobacterial Dendrubins

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Abstract: Anaerobic bacteria have only recently been recognized as a source of antibiotics; yet, the metabolic potential of Negativicutes (Gram‐negative staining Firmicutes) such as the oak‐associated Dendrosporobacter quercicolus has remained unknown. Genome mining of D. quercicolus and phylogenetic analyses revealed a gene cluster for a type II polyketide synthase (PKS) complex that belongs to the most ancestral enzyme systems of this type. Metabolic profiling, NMR analyses, and stable‐isotope labeling led to the discovery of a new family of anthraquinone‐type polyphenols, the dendrubins, which are diversified by acylation, methylation, and dimerization. Dendrubin A and B were identified as strong antibiotics against a range of clinically relevant, human‐pathogenic mycobacteria.

Standort
Deutsche Nationalbibliothek Frankfurt am Main
Umfang
Online-Ressource
Sprache
Englisch

Erschienen in
Oak‐Associated Negativicute Equipped with Ancestral Aromatic Polyketide Synthase Produces Antimycobacterial Dendrubins ; volume:26 ; number:58 ; year:2020 ; pages:13147-13151 ; extent:5
Chemistry - a European journal ; 26, Heft 58 (2020), 13147-13151 (gesamt 5)

Urheber
Ishida, Keishi
Shabuer, Gulimila
Schieferdecker, Sebastian
Pidot, Sacha J.
Stinear, Timothy P.
Knuepfer, Uwe
Cyrulies, Michael
Hertweck, Christian

DOI
10.1002/chem.202001939
URN
urn:nbn:de:101:1-2022060712592835846537
Rechteinformation
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
Letzte Aktualisierung
15.08.2024, 08:27 MESZ

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