Mesoporous silica nanoparticles as a drug delivery mechanism
Abstract: Research in intelligent drug delivery systems within the field of biomedicine promises to enhance drug efficacy at disease sites and reduce associated side effects. Mesoporous silica nanoparticles (MSNs), characterized by their large specific surface area, appropriate pore size, and excellent biocompatibility, have garnered significant attention as one of the most effective carriers for drug delivery. The hydroxyl groups on their surface are active functional groups, facilitating easy functionalization. The installation of controllable molecular machines on the surface of mesoporous silica to construct nanovalves represents a crucial advancement in developing intelligent drug delivery systems (DDSs) and addressing the issue of premature drug release. In this review, we compile several notable and illustrative examples of MSNs and discuss their varied applications in DDSs. These applications span regulated and progressive drug release mechanisms. MSNs hold the potential to enhance drug solubility, improve drug stability, and mitigate drug toxicity, attributable to their ease of functionalization. Furthermore, intelligent hybrid nanomaterials are being developed, featuring programmable properties that react to a broad spectrum of stimuli, including light, pH, enzymes, and redox triggers, through the use of molecular and supramolecular switches.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Mesoporous silica nanoparticles as a drug delivery mechanism ; volume:19 ; number:1 ; year:2024 ; extent:7
Open life sciences ; 19, Heft 1 (2024) (gesamt 7)
- Creator
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Zhang, Wei
Liu, Hongwei
Qiu, Xilong
Zuo, Fanjiao
Wang, Boyao
- DOI
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10.1515/biol-2022-0867
- URN
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urn:nbn:de:101:1-2405151612348.753374729869
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 10:52 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Zhang, Wei
- Liu, Hongwei
- Qiu, Xilong
- Zuo, Fanjiao
- Wang, Boyao
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