Cognitive deficits in parkinson's disease are associated with neuronal dysfunction and not white matter lesions
Abstract: Background
Cognitive deficits considerably contribute to the patient's burden in Parkinson's disease (PD). While cognitive decline is linked to neuronal dysfunction, the additional role of white matter lesions (WML) is discussed controversially.
Objective
To investigate the influence of WML, in comparison to neuronal dysfunction, on cognitive deficits in PD.
Methods
We prospectively recruited patients with PD who underwent neuropsychological assessment using the Mattis Dementia Rating Scale 2 (DRS-2) or Parkinson Neuropsychometric Dementia Assessment (PANDA) and both MRI and PET with [18F]fluorodeoxyglucose (FDG). WML-load and PD cognition-related covariance pattern (PDCP) as a measure of neuronal dysfunction were read out. Relationship between cognitive performance and rank-transformed WML was analyzed with linear regression, controlling for the patients’ age. PDCP subject scores were investigated likewise and in a second step adjusting for age and WML load.
Results
Inclusion criteria were met by 76 patients with a mean (± SD) age of 63.5 ± 9.0 years and disease duration of 10.7 ± 5.4 years. Neuropsychological testing revealed front executive and parietal deficits and a median DRS-2 score of 137 (range 119–144)/144 and PANDA score of 22 (range 3–30)/30. No association between WML and cognition was observed, whereas PDCP subject scores showed a trend-level negative correlation with the DRS-2 (P = 0.060) as well as a negative correlation with PANDA (P = 0.049) which persisted also after additional correction for WML (P = 0.039).
Conclusion
The present study indicates that microangiopathic WML do not have a relevant impact on neurocognitive performance in PD whereas neuronal dysfunction does
- Location
-
Deutsche Nationalbibliothek Frankfurt am Main
- Extent
-
Online-Ressource
- Language
-
Englisch
- Notes
-
Movement disorders clinical practice. - 10, 7 (2023) , 1066-1073, ISSN: 2330-1619
- Event
-
Veröffentlichung
- (where)
-
Freiburg
- (who)
-
Universität
- (when)
-
2023
- DOI
-
10.1002/mdc3.13792
- URN
-
urn:nbn:de:bsz:25-freidok-2371205
- Rights
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
-
25.03.2025, 1:43 PM CET
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
Time of origin
- 2023
Other Objects (12)
Der frische ischämische Schlaganfall : bildgebende Diagnostik und interventionelle Therapie
MRI in epilepsy
Freiburg neuropathology case conference : : a 42-year-old patient with progressive neurological deficits, multiple brain lesions and accompanying affection of peripheral nerves
Machine outputs must be checked
Quantitative fMRT-Bildgebungsstudie zu zerebralen Verarbeitungswegen bei Bewegung zu Musik in Parkinson-Patienten
Anatomische Variabilität des Nucleus subthalamicus und seiner funktionellen Anteile : potentieller Einfluss des Volumens des adressierten motorischen Funktionsbereiches auf das motorische Outcome im Rahmen der Tiefen Hirnstimulation bei Morbus Parkinson
Safety of endovascular treatment in acute stroke patients taking oral anticoagulants
Obsessive–compulsive symptoms and brain lesions compatible with multiple sclerosis
Multiple bilateral CSF-venous fistulas in spontaneous intracranial hypotension : : a therapeutic challenge
Clinical utility of principal components analysis on PET data in the prediction of Alzheimer’s disease dementia
Teaching neuroimages: dynamic digital subtraction myelography discloses a ventral CSF leak in a patient with upper limb amyotrophy
Disentangling nigral and putaminal contribution to motor impairment and levodopa response in Parkinson’s disease
Der frische ischämische Schlaganfall : bildgebende Diagnostik und interventionelle Therapie
MRI in epilepsy
Freiburg neuropathology case conference : : a 42-year-old patient with progressive neurological deficits, multiple brain lesions and accompanying affection of peripheral nerves
Machine outputs must be checked
Quantitative fMRT-Bildgebungsstudie zu zerebralen Verarbeitungswegen bei Bewegung zu Musik in Parkinson-Patienten
Anatomische Variabilität des Nucleus subthalamicus und seiner funktionellen Anteile : potentieller Einfluss des Volumens des adressierten motorischen Funktionsbereiches auf das motorische Outcome im Rahmen der Tiefen Hirnstimulation bei Morbus Parkinson
Safety of endovascular treatment in acute stroke patients taking oral anticoagulants
Obsessive–compulsive symptoms and brain lesions compatible with multiple sclerosis
Multiple bilateral CSF-venous fistulas in spontaneous intracranial hypotension : : a therapeutic challenge
Clinical utility of principal components analysis on PET data in the prediction of Alzheimer’s disease dementia
Teaching neuroimages: dynamic digital subtraction myelography discloses a ventral CSF leak in a patient with upper limb amyotrophy
Disentangling nigral and putaminal contribution to motor impairment and levodopa response in Parkinson’s disease
Der frische ischämische Schlaganfall : bildgebende Diagnostik und interventionelle Therapie
MRI in epilepsy
Freiburg neuropathology case conference : : a 42-year-old patient with progressive neurological deficits, multiple brain lesions and accompanying affection of peripheral nerves
Machine outputs must be checked
Quantitative fMRT-Bildgebungsstudie zu zerebralen Verarbeitungswegen bei Bewegung zu Musik in Parkinson-Patienten
Anatomische Variabilität des Nucleus subthalamicus und seiner funktionellen Anteile : potentieller Einfluss des Volumens des adressierten motorischen Funktionsbereiches auf das motorische Outcome im Rahmen der Tiefen Hirnstimulation bei Morbus Parkinson
Safety of endovascular treatment in acute stroke patients taking oral anticoagulants
Obsessive–compulsive symptoms and brain lesions compatible with multiple sclerosis
Multiple bilateral CSF-venous fistulas in spontaneous intracranial hypotension : : a therapeutic challenge
Clinical utility of principal components analysis on PET data in the prediction of Alzheimer’s disease dementia
Teaching neuroimages: dynamic digital subtraction myelography discloses a ventral CSF leak in a patient with upper limb amyotrophy