Blue Laser Triggered Hemostatic Peptide Hydrogel for Gastrointestinal Bleeding Treatment

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Abstract: In an emergency, nonvariceal upper gastrointestinal bleeding (NVUGIB), endoscopic hemostasis is considered the gold standard intervention. However, current endoscopic hemostasis is very challenging to manage bleeding in large‐diameter or deep lesions highly prone to rebleeding risk. Herein, a novel hemostatic peptide hydrogel (HPH) is reported, consisting of a self‐assembly peptide sequence CFLIVIGSIIVPGDGVPGDG (PFV) and gelatin methacryloyl (GelMA), which can be triggered by blue laser endoscopy (BLE) for nonvariceal upper gastrointestinal bleeding treatment without recurring bleeding concerns. Upon contact with GelMA solution, PFV immediately fibrillates into β‐sheet nanofiber and solvent‐induced self‐assembly to form HPH gel. HPH nanofiber networks induced ultrafast coagulation by enveloping blood cells and activating platelets and coagulation factors even to the blood with coagulopathy. Besides its remarkable hemostatic performance in artery and liver injury models, HPH achieves instant bleeding management in porcine NVUGIB models within 60 s by preventing the rebleeding risk. This work demonstrates an extraordinary hemostatic agent for NVUGIB intervention by BLE for the first time, broadening potential application scenarios, including patients with coagulopathy and promising clinical prospects.

Standort
Deutsche Nationalbibliothek Frankfurt am Main
Umfang
Online-Ressource
Sprache
Englisch

Erschienen in
Blue Laser Triggered Hemostatic Peptide Hydrogel for Gastrointestinal Bleeding Treatment ; day:16 ; month:07 ; year:2024 ; extent:20
Advanced materials ; (16.07.2024) (gesamt 20)

Urheber
Luo, Qiang
Luo, Jie
Luan, Zhaohui
Xu, Kaige
Tian, Lixing
Zhang, Kebin
Peng, Xue
Yuan, Mengxue
Zheng, Chuanhao
Shu, Zhenzhen
Zhang, Yuchen
Tan, Shali
Dan, Ruijue
Mequanint, Kibret
Fan, Chaoqiang
Xing, Malcolm
Yang, Shiming

DOI
10.1002/adma.202405290
URN
urn:nbn:de:101:1-2407161440533.890210111499
Rechteinformation
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
Letzte Aktualisierung
14.08.2025, 10:57 MESZ

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Beteiligte

  • Luo, Qiang
  • Luo, Jie
  • Luan, Zhaohui
  • Xu, Kaige
  • Tian, Lixing
  • Zhang, Kebin
  • Peng, Xue
  • Yuan, Mengxue
  • Zheng, Chuanhao
  • Shu, Zhenzhen
  • Zhang, Yuchen
  • Tan, Shali
  • Dan, Ruijue
  • Mequanint, Kibret
  • Fan, Chaoqiang
  • Xing, Malcolm
  • Yang, Shiming

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