Blue Laser Triggered Hemostatic Peptide Hydrogel for Gastrointestinal Bleeding Treatment
Abstract: In an emergency, nonvariceal upper gastrointestinal bleeding (NVUGIB), endoscopic hemostasis is considered the gold standard intervention. However, current endoscopic hemostasis is very challenging to manage bleeding in large‐diameter or deep lesions highly prone to rebleeding risk. Herein, a novel hemostatic peptide hydrogel (HPH) is reported, consisting of a self‐assembly peptide sequence CFLIVIGSIIVPGDGVPGDG (PFV) and gelatin methacryloyl (GelMA), which can be triggered by blue laser endoscopy (BLE) for nonvariceal upper gastrointestinal bleeding treatment without recurring bleeding concerns. Upon contact with GelMA solution, PFV immediately fibrillates into β‐sheet nanofiber and solvent‐induced self‐assembly to form HPH gel. HPH nanofiber networks induced ultrafast coagulation by enveloping blood cells and activating platelets and coagulation factors even to the blood with coagulopathy. Besides its remarkable hemostatic performance in artery and liver injury models, HPH achieves instant bleeding management in porcine NVUGIB models within 60 s by preventing the rebleeding risk. This work demonstrates an extraordinary hemostatic agent for NVUGIB intervention by BLE for the first time, broadening potential application scenarios, including patients with coagulopathy and promising clinical prospects.
- Location
-
Deutsche Nationalbibliothek Frankfurt am Main
- Extent
-
Online-Ressource
- Language
-
Englisch
- Bibliographic citation
-
Blue Laser Triggered Hemostatic Peptide Hydrogel for Gastrointestinal Bleeding Treatment ; day:16 ; month:07 ; year:2024 ; extent:20
Advanced materials ; (16.07.2024) (gesamt 20)
- Creator
-
Luo, Qiang
Luo, Jie
Luan, Zhaohui
Xu, Kaige
Tian, Lixing
Zhang, Kebin
Peng, Xue
Yuan, Mengxue
Zheng, Chuanhao
Shu, Zhenzhen
Zhang, Yuchen
Tan, Shali
Dan, Ruijue
Mequanint, Kibret
Fan, Chaoqiang
Xing, Malcolm
Yang, Shiming
- DOI
-
10.1002/adma.202405290
- URN
-
urn:nbn:de:101:1-2407161440533.890210111499
- Rights
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
-
14.08.2025, 10:57 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Luo, Qiang
- Luo, Jie
- Luan, Zhaohui
- Xu, Kaige
- Tian, Lixing
- Zhang, Kebin
- Peng, Xue
- Yuan, Mengxue
- Zheng, Chuanhao
- Shu, Zhenzhen
- Zhang, Yuchen
- Tan, Shali
- Dan, Ruijue
- Mequanint, Kibret
- Fan, Chaoqiang
- Xing, Malcolm
- Yang, Shiming
Other Objects (12)
Traveling wave solution and qualitative behavior of fractional stochastic Kraenkel–Manna–Merle equation in ferromagnetic materials
Dynamical analysis and the soliton solutions of (2+1)-dimensional Heisenberg ferro-magnetic spin chains model with beta fractional derivative
Interpretation for practice guidelines for prevention, diagnosis, and treatment of ventilator-associated pneumonia in burn patients by american burn association
Effects of black carbon morphology on brown carbon absorption estimation: from numerical aspects
Effects of black carbon morphology on the brown carbon absorption estimation: from numerical aspects
In Situ Polymer Gel Electrolyte in Boosting Scalable Fibre Lithium Battery Applications
A novel role of LncRNA in regulating tumor metabolism and angiogenesis under hypoxia
Effects of brown coatings on the absorption enhancement of black carbon: a numerical investigation
Construction of a model for adolescent physical and mental health promotion based on the multiple mediating effects of general self-efficacy and sleep duration
Pseudo‐Hermitian Systems Constructed by Transformation Optics with Robustly Balanced Loss and Gain
On the Asymptotic Expansions of the Proper Harmonic Maps Between Balls in Bergman Metrics
BioRel: towards large-scale biomedical relation extraction
Traveling wave solution and qualitative behavior of fractional stochastic Kraenkel–Manna–Merle equation in ferromagnetic materials
Dynamical analysis and the soliton solutions of (2+1)-dimensional Heisenberg ferro-magnetic spin chains model with beta fractional derivative
Interpretation for practice guidelines for prevention, diagnosis, and treatment of ventilator-associated pneumonia in burn patients by american burn association
Effects of black carbon morphology on brown carbon absorption estimation: from numerical aspects
Effects of black carbon morphology on the brown carbon absorption estimation: from numerical aspects
In Situ Polymer Gel Electrolyte in Boosting Scalable Fibre Lithium Battery Applications
A novel role of LncRNA in regulating tumor metabolism and angiogenesis under hypoxia
Effects of brown coatings on the absorption enhancement of black carbon: a numerical investigation
Construction of a model for adolescent physical and mental health promotion based on the multiple mediating effects of general self-efficacy and sleep duration
Pseudo‐Hermitian Systems Constructed by Transformation Optics with Robustly Balanced Loss and Gain
On the Asymptotic Expansions of the Proper Harmonic Maps Between Balls in Bergman Metrics
BioRel: towards large-scale biomedical relation extraction
Traveling wave solution and qualitative behavior of fractional stochastic Kraenkel–Manna–Merle equation in ferromagnetic materials
Dynamical analysis and the soliton solutions of (2+1)-dimensional Heisenberg ferro-magnetic spin chains model with beta fractional derivative
Interpretation for practice guidelines for prevention, diagnosis, and treatment of ventilator-associated pneumonia in burn patients by american burn association
Effects of black carbon morphology on brown carbon absorption estimation: from numerical aspects
Effects of black carbon morphology on the brown carbon absorption estimation: from numerical aspects
In Situ Polymer Gel Electrolyte in Boosting Scalable Fibre Lithium Battery Applications
A novel role of LncRNA in regulating tumor metabolism and angiogenesis under hypoxia
Effects of brown coatings on the absorption enhancement of black carbon: a numerical investigation
Construction of a model for adolescent physical and mental health promotion based on the multiple mediating effects of general self-efficacy and sleep duration
Pseudo‐Hermitian Systems Constructed by Transformation Optics with Robustly Balanced Loss and Gain
On the Asymptotic Expansions of the Proper Harmonic Maps Between Balls in Bergman Metrics