Photocatalytic C−H Functionalization of Nitrogen Heterocycles Mediated by a Redox Active Protecting Group
Abstract: Herein, we report a photocatalytic strategy for the C−H functionalization of saturated azaheterocycles under mild conditions with only one equivalent of starting material. Our strategy is based on a redox active benzamide protecting group that is activated via a halogen‐atom transfer (XAT) process to trigger the formation of an α‐amino radical. This nucleophilic radical intermediate was then engaged in Giese additions and radical cross couplings to afford C−H alkylated and arylated products.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Photocatalytic C−H Functionalization of Nitrogen Heterocycles Mediated by a Redox Active Protecting Group ; day:31 ; month:08 ; year:2023 ; extent:6
European journal of organic chemistry ; (31.08.2023) (gesamt 6)
- Creator
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Pizzio, Marianela G.
Mata, Ernesto G.
Dauban, Philippe
Saget, Tanguy
- DOI
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10.1002/ejoc.202300616
- URN
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urn:nbn:de:101:1-2023083115472477715618
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 10:56 AM CEST
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Associated
- Pizzio, Marianela G.
- Mata, Ernesto G.
- Dauban, Philippe
- Saget, Tanguy
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