SSTR2 in nasopharyngeal carcinoma: relationship with latent EBV infection and potential as a therapeutic target

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Abstract: Nasopharyngeal carcinoma (NPC) is a malignant epithelial tumor, most commonly located in the pharyngeal recess and endemic to parts of Asia. It is often detected at a late stage which is associated with poor prognosis (5-year survival rate of 63%). Treatment for this malignancy relies predominantly on radiotherapy and/or systemic chemotherapy, which can be associated with significant morbidity and impaired quality of life. In endemic regions NPC is associated with infection by Epstein–Barr virus (EBV) which was shown to upregulate the somatostatin receptor 2 (SSTR2) cell surface receptor. With recent advances in molecular techniques allowing for an improved understanding of the molecular aetiology of this disease and its relation to SSTR2 expression, we provide a comprehensive and up-to-date overview of this disease and highlight the emergence of SSTR2 as a key tumor biomarker and promising target for imaging and therapy

Standort
Deutsche Nationalbibliothek Frankfurt am Main
Umfang
Online-Ressource
Sprache
Englisch
Anmerkungen
Cancers. - 13, 19 (2021) , 4944, ISSN: 2072-6694

Ereignis
Veröffentlichung
(wo)
Freiburg
(wer)
Universität
(wann)
2021
Urheber
Emanuel, Oscar
Liu, Jacklyn
Schartinger, Volker H.
Nei, Wen Long
Chan, Yuk Yu
Tsang, Chi Man
Riechelmann, Herbert
Masterson, Liam
Haybäck, Johannes
Oppermann, Udo
Willems, Stefan M.
Ooft, Marc L.
Wollmann, Guido
Howard, David J.
Vanhaesebroeck, Bart
Lund, Valerie J.
Royle, Gary
Chua, Melvin L. K.
Lo, Kwok Wai
Busson, Pierre
Lechner, Matt

DOI
10.3390/cancers13194944
URN
urn:nbn:de:bsz:25-freidok-2226565
Rechteinformation
Kein Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
Letzte Aktualisierung
15.08.2025, 07:38 MESZ

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Beteiligte

  • Emanuel, Oscar
  • Liu, Jacklyn
  • Schartinger, Volker H.
  • Nei, Wen Long
  • Chan, Yuk Yu
  • Tsang, Chi Man
  • Riechelmann, Herbert
  • Masterson, Liam
  • Haybäck, Johannes
  • Oppermann, Udo
  • Willems, Stefan M.
  • Ooft, Marc L.
  • Wollmann, Guido
  • Howard, David J.
  • Vanhaesebroeck, Bart
  • Lund, Valerie J.
  • Royle, Gary
  • Chua, Melvin L. K.
  • Lo, Kwok Wai
  • Busson, Pierre
  • Lechner, Matt
  • Universität

Entstanden

  • 2021

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