Arbeitspapier
Tests in a Case-Control Design Including Relatives
We present a new approach to handle dependencies within the general framework of case-control designs, illustrating our approach by a particular application from the field of genetic epidemiology. The method is derived for parent-offspring trios, which will later be relaxed to more general family structures. For applications in genetic epidemiology we consider tests on equality of allele frequencies among cases and controls utilizing well-known risk measures to test for independence of phenotype and genotype at the observed locus. These test statistics are derived as functions of the entries in the associated contingency table containing the numbers of the alleles under consideration in the case and the control group. We find the joint asymptotic distribution of these entries, which enables us to derive critical values for any test constructed on this basis. A simulation study reveals the finite sample behavior of our test statistics.
- Sprache
-
Englisch
- Erschienen in
-
Series: Technical Report ; No. 2006,05
- Thema
-
association tests
contingency tables
dependent data
risk measures
- Ereignis
-
Geistige Schöpfung
- (wer)
-
Biedermann, Stefanie
Nagel, Eva-Renate
Munk, Axel
Holzmann, Hajo
Steland, Ansgar
- Ereignis
-
Veröffentlichung
- (wer)
-
Universität Dortmund, Sonderforschungsbereich 475 - Komplexitätsreduktion in Multivariaten Datenstrukturen
- (wo)
-
Dortmund
- (wann)
-
2006
- Handle
- Letzte Aktualisierung
-
10.03.2025, 11:42 MEZ
Datenpartner
ZBW - Deutsche Zentralbibliothek für Wirtschaftswissenschaften - Leibniz-Informationszentrum Wirtschaft. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Objekttyp
- Arbeitspapier
Beteiligte
- Biedermann, Stefanie
- Nagel, Eva-Renate
- Munk, Axel
- Holzmann, Hajo
- Steland, Ansgar
- Universität Dortmund, Sonderforschungsbereich 475 - Komplexitätsreduktion in Multivariaten Datenstrukturen
Entstanden
- 2006
Ähnliche Objekte (12)
Tests in a Case-Control Design Including Relatives
Case-control association tests correcting for Population stratification
Causal inference in case-control studies
The case-control study consensus and controversy
Dynamic inference in general nested case‐control designs
Activated matrix metalloproteinase‑8 in saliva as diagnostic test for periodontal disease? A case–control study
Percutaneous versus open Achilles tendon repair : a case-control study
C-tactile touch perception in migraineurs – a case-control study
Dietary acid load and esophageal cancer risk: a case‐control study
Gene expression studies : from case-control to multiple-population-based studies
Analysis of a case-control study concerning bladder cancer and occupational exposures
Dietary acid load and bladder cancer risk: an epidemiologic case-control study
Tests in a Case-Control Design Including Relatives
Case-control association tests correcting for Population stratification
Causal inference in case-control studies
The case-control study consensus and controversy
Dynamic inference in general nested case‐control designs
Activated matrix metalloproteinase‑8 in saliva as diagnostic test for periodontal disease? A case–control study
Percutaneous versus open Achilles tendon repair : a case-control study
C-tactile touch perception in migraineurs – a case-control study
Dietary acid load and esophageal cancer risk: a case‐control study
Gene expression studies : from case-control to multiple-population-based studies
Analysis of a case-control study concerning bladder cancer and occupational exposures
Dietary acid load and bladder cancer risk: an epidemiologic case-control study
Tests in a Case-Control Design Including Relatives
Case-control association tests correcting for Population stratification
Causal inference in case-control studies
The case-control study consensus and controversy
Dynamic inference in general nested case‐control designs
Activated matrix metalloproteinase‑8 in saliva as diagnostic test for periodontal disease? A case–control study
Percutaneous versus open Achilles tendon repair : a case-control study
C-tactile touch perception in migraineurs – a case-control study
Dietary acid load and esophageal cancer risk: a case‐control study
Gene expression studies : from case-control to multiple-population-based studies
Analysis of a case-control study concerning bladder cancer and occupational exposures