The Intestinal Transporter SLC30A1 Plays a Critical Role in Regulating Systemic Zinc Homeostasis
Abstract: The essential trace element, zinc, regulates virtually all aspects of cellular physiology, particularly cell proliferation and survival. Diverse families of metal transporters, metallothioneins, and metal‐responsive transcriptional regulators are linked to zinc homeostasis. However, the mechanism underlying the regulation of systemic zinc homeostasis remains largely unknown. Here, it is reported that the intestinal transporter SLC30A1 plays an essential role in maintaining systemic zinc homeostasis. Using several lines of tissue‐specific knockout mice, it is found that intestinal Slc30a1 plays a critical role in survival. Furthermore, lineage tracing reveals that Slc30a1 is localized to the basolateral membrane of intestinal epithelial cells (IECs). It is also found that Slc30a1 safeguards both intestinal barrier integrity and systemic zinc homeostasis. Finally, an integrative analysis of the cryo‐EM structure and site‐specific mutagenesis of human SLC30A1 are performed and a zinc transport mechanism of SLC30A1 unique within the SLC30A family, with His43 serving as a critical residue for zinc selectivity, is identified.
- Location
-
Deutsche Nationalbibliothek Frankfurt am Main
- Extent
-
Online-Ressource
- Language
-
Englisch
- Bibliographic citation
-
The Intestinal Transporter SLC30A1 Plays a Critical Role in Regulating Systemic Zinc Homeostasis ; day:18 ; month:10 ; year:2024 ; extent:18
Advanced science ; (18.10.2024) (gesamt 18)
- Creator
-
Sun, Shumin
Xie, Enjun
Xu, Shan
Ji, Suyu
Wang, Shufen
Shen, Jie
Wang, Rong
Shen, Xinyi
Su, Yunxing
Song, Zijun
Wu, Xiaotian
Zhou, Jiahui
Cai, Zhaoxian
Li, Xiaopeng
Zhang, Yan
Min, Junxia
Wang, Fudi
- DOI
-
10.1002/advs.202406421
- URN
-
urn:nbn:de:101:1-2410181505437.019354769722
- Rights
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
-
15.08.2025, 7:34 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Sun, Shumin
- Xie, Enjun
- Xu, Shan
- Ji, Suyu
- Wang, Shufen
- Shen, Jie
- Wang, Rong
- Shen, Xinyi
- Su, Yunxing
- Song, Zijun
- Wu, Xiaotian
- Zhou, Jiahui
- Cai, Zhaoxian
- Li, Xiaopeng
- Zhang, Yan
- Min, Junxia
- Wang, Fudi
Other Objects (12)
Approaches to international industrial relations in Chinese Multinational Corporations
Presenilins in Alzheimer’s disease and frontotemporal dementia
Function and dysfunction of presenilin in Alzheimer’s disease
Global emission inventory and atmospheric transport of black carbon : evaluation of the associated exposure
Presenilins are required for maintenance of neural stem cells in the developing brain
Regulation of mitochondrial function by PINK1, Parkin and DJ-1
Absence of dopaminergic neuronal degeneration and oxidative damage in aged DJ-1-deficient mice
Cell-autonomous role of Presenilin in age-dependent survival of cortical interneurons
Preliminary study on knowledge graph construction based on the coupling mechanism of urban disaster and emergency response
Knowledge transfer and boundary conditions: A study of SMEs in business incubation centers in China
Predictors of mobile internet usage in 10 African countries
The relation of dental students’ learning styles to their satisfaction with traditional and inverted classroom models
Approaches to international industrial relations in Chinese Multinational Corporations
Presenilins in Alzheimer’s disease and frontotemporal dementia
Function and dysfunction of presenilin in Alzheimer’s disease
Global emission inventory and atmospheric transport of black carbon : evaluation of the associated exposure
Presenilins are required for maintenance of neural stem cells in the developing brain
Regulation of mitochondrial function by PINK1, Parkin and DJ-1
Absence of dopaminergic neuronal degeneration and oxidative damage in aged DJ-1-deficient mice
Cell-autonomous role of Presenilin in age-dependent survival of cortical interneurons
Preliminary study on knowledge graph construction based on the coupling mechanism of urban disaster and emergency response
Knowledge transfer and boundary conditions: A study of SMEs in business incubation centers in China
Predictors of mobile internet usage in 10 African countries
The relation of dental students’ learning styles to their satisfaction with traditional and inverted classroom models
Approaches to international industrial relations in Chinese Multinational Corporations
Presenilins in Alzheimer’s disease and frontotemporal dementia
Function and dysfunction of presenilin in Alzheimer’s disease
Global emission inventory and atmospheric transport of black carbon : evaluation of the associated exposure
Presenilins are required for maintenance of neural stem cells in the developing brain
Regulation of mitochondrial function by PINK1, Parkin and DJ-1
Absence of dopaminergic neuronal degeneration and oxidative damage in aged DJ-1-deficient mice
Cell-autonomous role of Presenilin in age-dependent survival of cortical interneurons
Preliminary study on knowledge graph construction based on the coupling mechanism of urban disaster and emergency response
Knowledge transfer and boundary conditions: A study of SMEs in business incubation centers in China
Predictors of mobile internet usage in 10 African countries