Isovitexin modulates autophagy in Alzheimer’s disease via miR-107 signalling
Background:: Alzheimer’s disease (AD) is an ultimately fatal, degenerative brain disease in the elderly people. In the current work, we assessed the defensive capability of isovitexin (IVX) through an intracerebroventricular injection of streptozotocin (STZ)-induced AD mouse model. Methods:: Mice were separated into four cohorts: sham-operated control mice; STZ-intoxicated Alzheimer’s mice; IVX cohort, IVX + STZ; and Ant-107 cohort, antagomiR-107 + IVX/STZ as in the IVX cohort. Results:: The outcomes indicated that IVX administration ameliorated spatial memory loss and blunted a cascade of neuro-noxious episodes – including increased amyloid-beta (Aβ) and degraded myelin basic protein burden, neuroinflammation (represented by elevated caspase-1, TNF-α and IL-6 levels) and autophagic dysfunction (represented by altered LC3-II, Atg7 and beclin-1 expressions) – via the inhibition of PI3K/Akt/mTOR signalling axis. We considered the question of whether the epigenetic role of microRNA-107 (miR-107) has any impact on these events, by using antagomiR-107. Conclusion:: This probing underscored that miR-107 could be a pivotal regulatory button in the activation of molecular signals linked with the beneficial autophagic process and anti-inflammatory activities in relation to IVX treatment. Hence, this report exemplifies that IVX could guard against Aβ toxicity and serve as an effectual treatment for patients afflicted with AD.
- Location
-
Deutsche Nationalbibliothek Frankfurt am Main
- Extent
-
Online-Ressource
- Language
-
Englisch
- Bibliographic citation
-
Isovitexin modulates autophagy in Alzheimer’s disease via miR-107 signalling ; volume:11 ; number:1 ; year:2020 ; pages:391-401 ; extent:11
Translational Neuroscience ; 11, Heft 1 (2020), 391-401 (gesamt 11)
- Creator
-
Cheng, Jiang
Wang, Guowei
Zhang, Na
Li, Fang
Shi, Lina
Li, Haining
- DOI
-
10.1515/tnsci-2020-0109
- URN
-
urn:nbn:de:101:1-2022111513161556598394
- Rights
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
-
15.08.2025, 7:36 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Cheng, Jiang
- Wang, Guowei
- Zhang, Na
- Li, Fang
- Shi, Lina
- Li, Haining
Other Objects (12)
Retraction of “Isovitexin modulates autophagy in Alzheimer’s disease via miR-107 signalling”
Finite spectrum of fourth-order boundary value problems with boundary and transmission conditions dependent on the spectral parameter
Association between handgrip strength and cognition in a Chinese population with Alzheimer’s disease and mild cognitive impairment
Anforderungsermittlung an ein Beschreibungsmittel und Erweiterung einer Gerätebeschreibungssprache für die modulare Automatisierung im Maschinen- und Anlagenbau
“Are you there?”: Teaching presence and interaction in large online literature classes
Association Between the Risk of Dental Caries and DLX3 Gene Polymorphisms in Chinese Children
Nutritional characteristics and health effects of regional cuisines in China
Fibre Processes and their Applications
A dynamic directed transfer function for brain functional network-based feature extraction
Doubly elastic net regularized online portfolio optimization with transaction costs
Crystal structure of N 2, N 6 -bis (2-(((Z)-5-bromo-2-hydroxybenzylidene) amino) phenyl) pyridine-2,6-dicarboxamide, C 33 H 23 Br 2 N 5 O 4
Effect of Fe impregnation sequence on ethanol synthesis from syngas over Mn and Fe promoted Rh/γ-Al2O3
Retraction of “Isovitexin modulates autophagy in Alzheimer’s disease via miR-107 signalling”
Finite spectrum of fourth-order boundary value problems with boundary and transmission conditions dependent on the spectral parameter
Association between handgrip strength and cognition in a Chinese population with Alzheimer’s disease and mild cognitive impairment
Anforderungsermittlung an ein Beschreibungsmittel und Erweiterung einer Gerätebeschreibungssprache für die modulare Automatisierung im Maschinen- und Anlagenbau
“Are you there?”: Teaching presence and interaction in large online literature classes
Association Between the Risk of Dental Caries and DLX3 Gene Polymorphisms in Chinese Children
Nutritional characteristics and health effects of regional cuisines in China
Fibre Processes and their Applications
A dynamic directed transfer function for brain functional network-based feature extraction
Doubly elastic net regularized online portfolio optimization with transaction costs
Crystal structure of N 2, N 6 -bis (2-(((Z)-5-bromo-2-hydroxybenzylidene) amino) phenyl) pyridine-2,6-dicarboxamide, C 33 H 23 Br 2 N 5 O 4
Effect of Fe impregnation sequence on ethanol synthesis from syngas over Mn and Fe promoted Rh/γ-Al2O3
Retraction of “Isovitexin modulates autophagy in Alzheimer’s disease via miR-107 signalling”
Finite spectrum of fourth-order boundary value problems with boundary and transmission conditions dependent on the spectral parameter
Association between handgrip strength and cognition in a Chinese population with Alzheimer’s disease and mild cognitive impairment
Anforderungsermittlung an ein Beschreibungsmittel und Erweiterung einer Gerätebeschreibungssprache für die modulare Automatisierung im Maschinen- und Anlagenbau
“Are you there?”: Teaching presence and interaction in large online literature classes
Association Between the Risk of Dental Caries and DLX3 Gene Polymorphisms in Chinese Children
Nutritional characteristics and health effects of regional cuisines in China
Fibre Processes and their Applications
A dynamic directed transfer function for brain functional network-based feature extraction
Doubly elastic net regularized online portfolio optimization with transaction costs
Crystal structure of N 2, N 6 -bis (2-(((Z)-5-bromo-2-hydroxybenzylidene) amino) phenyl) pyridine-2,6-dicarboxamide, C 33 H 23 Br 2 N 5 O 4