Spinal meningeal melanocytoma
Primary melanotic meningeal neoplasms are extremely rare lesions and benign forms are even rarer though with better prognosis than the malignant ones. We describe a 40-year-old male with a history of gradually progressive weakness of both lower limbs with normal bowel, bladder control, and an intradural mass measuring 1.5×1.0 cm on radiologic investigations. The lesion was surgically excised. Histopathologic examination revealed heavily melanin-pigmented cells, nuclei with reticulogranular chromatin and small nucleoli, moderate amount of eosinophillic cytoplasm with indistinct cell boundaries, and symplasmic appearance. A probable diagnosis of meningeal melanocytoma was made. The diagnosis was confirmed on immunohistochemical analysis which revealed strongly positive expression of HMB-45 in the tumor cells. Vimentin and S-100 were also diffusely positive while neuron specific enolase showed focal and patchy positivity; however, epithelial membrane antigen was distinctly negative.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Spinal meningeal melanocytoma ; volume:6 ; number:02 ; year:2011 ; pages:110-112
Asian journal of neurosurgery ; 6, Heft 02 (2011), 110-112
- Contributor
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Sen, Rajeev
Sethi, Divya
Goyal, Vandana
Duhan, Amrita
Modi, Shilpi
- DOI
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10.4103/1793-5482.92176
- URN
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urn:nbn:de:101:1-2022120112434838346847
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:30 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Sen, Rajeev
- Sethi, Divya
- Goyal, Vandana
- Duhan, Amrita
- Modi, Shilpi
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