HDAC8 : : a multifaceted target for therapeutic interventions

Abstract: Histone deacetylase 8 (HDAC8) is a class I histone deacetylase implicated as a therapeutic target in various diseases, including cancer, X-linked intellectual disability, and parasitic infections. It is a structurally well-characterized enzyme that also deacetylates nonhistone proteins. In cancer, HDAC8 is a major ‘epigenetic player’ that is linked to deregulated expression or interaction with transcription factors critical to tumorigenesis. In the parasite Schistosoma mansoni and in viral infections, HDAC8 is a novel target to subdue infection. The current challenge remains in the development of potent selective inhibitors that would specifically target HDAC8 with fewer adverse effects compared with pan-HDAC inhibitors. Here, we review HDAC8 as a drug target and discuss inhibitors with respect to their structural features and therapeutic interventions

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

Classification and Topics

• Keyword: Inhibitor ; Histon-Deacetylase ; Lange-Syndrom ; Krebs ; Pärchenegel ; Röntgenkristallographie

Contributors, Places and Time

• Event: Veröffentlichung
• (where): Freiburg
• (who): Universität
• (when): 2017
• Creator: Chakrabarti, Alokta ; Oehme, Ina ; Witt, Olaf ; Oliveira, Guilherme ; Sippl, Wolfgang ; Romier, Christophe ; Pierce, Raymond J. ; Jung, Manfred

Further information

• DOI: 10.1016/j.tips.2015.04.013
• URN: urn:nbn:de:bsz:25-freidok-123993
• Rights: Kein Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 25.03.2025, 1:42 PM CET