HDAC8 : : a multifaceted target for therapeutic interventions
Abstract: Histone deacetylase 8 (HDAC8) is a class I histone deacetylase implicated as a therapeutic target in various diseases, including cancer, X-linked intellectual disability, and parasitic infections. It is a structurally well-characterized enzyme that also deacetylates nonhistone proteins. In cancer, HDAC8 is a major ‘epigenetic player’ that is linked to deregulated expression or interaction with transcription factors critical to tumorigenesis. In the parasite Schistosoma mansoni and in viral infections, HDAC8 is a novel target to subdue infection. The current challenge remains in the development of potent selective inhibitors that would specifically target HDAC8 with fewer adverse effects compared with pan-HDAC inhibitors. Here, we review HDAC8 as a drug target and discuss inhibitors with respect to their structural features and therapeutic interventions
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Schlagwort
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Inhibitor
Histon-Deacetylase
Lange-Syndrom
Krebs
Pärchenegel
Röntgenkristallographie
- Ereignis
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Veröffentlichung
- (wo)
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Freiburg
- (wer)
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Universität
- (wann)
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2017
- Urheber
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Chakrabarti, Alokta
Oehme, Ina
Witt, Olaf
Oliveira, Guilherme
Sippl, Wolfgang
Romier, Christophe
Pierce, Raymond J.
Jung, Manfred
- DOI
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10.1016/j.tips.2015.04.013
- URN
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urn:nbn:de:bsz:25-freidok-123993
- Rechteinformation
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Kein Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:33 MESZ
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Beteiligte
- Chakrabarti, Alokta
- Oehme, Ina
- Witt, Olaf
- Oliveira, Guilherme
- Sippl, Wolfgang
- Romier, Christophe
- Pierce, Raymond J.
- Jung, Manfred
- Universität
Entstanden
- 2017
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