Telomere length determinants in childhood
Abstract: Telomere length (TL) is a dynamic marker that reflects genetic predispositions together with the environmental conditions of an individual. It is closely related to longevity and a number of pathological conditions. Even though the extent of telomere research in children is limited compared to that of adults, there have been a substantial number of studies providing first insights into child telomere biology and determinants. Recent discoveries revealed evidence that TL is, to a great extent, determined already in childhood and that environmental conditions in adulthood have less impact than first believed. Studies have demonstrated that large inter-individual differences in TL are present among newborns and are determined by diverse factors that influence intrauterine development. The first years of child growth are associated with high cellular turnover, which results in fast shortening of telomeres. The rate of telomere loss becomes stable in early adulthood. In this review article we summarise the existing knowledge on telomere dynamics during the first years of childhood, highlighting the conditions that affect newborn TL. We also warn about the knowledge gaps that should be filled to fully understand the regulation of telomeres, in order to implement them as biomarkers for use in diagnostics or treatment.
- Location
-
Deutsche Nationalbibliothek Frankfurt am Main
- Extent
-
Online-Ressource
- Language
-
Englisch
- Bibliographic citation
-
Telomere length determinants in childhood ; volume:58 ; number:2 ; year:2020 ; pages:162-177 ; extent:16
Clinical chemistry and laboratory medicine ; 58, Heft 2 (2020), 162-177 (gesamt 16)
- Creator
-
Gorenjak, Vesna
Petrelis, Alexandros M.
Stathopoulou, Maria G.
Visvikis-Siest, Sophie
- DOI
-
10.1515/cclm-2019-0235
- URN
-
urn:nbn:de:101:1-2022053115311035985810
- Rights
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
-
15.08.2025, 7:21 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Gorenjak, Vesna
- Petrelis, Alexandros M.
- Stathopoulou, Maria G.
- Visvikis-Siest, Sophie
Other Objects (12)
Genetic Determinants of Telomere Length in African American Youth
Unraveling the causal genes and transcriptomic determinants of human telomere length
Peripartum depression symptom trajectories, telomere length and genotype, and adverse childhood experiences
Telomere Length: Implications for Atherogenesis
Telomere length: how the length makes a difference
Adverse childhood experiences, epigenetics and telomere length variation in childhood and beyond: a systematic review of the literature
Alcohol consumption and leukocyte telomere length
Mathematical modelling of telomere length dynamics
Telomere length and human hippocampal neurogenesis
Genetic predisposition to longer telomere length and risk of childhood, adolescent and adult-onset ependymoma
Bovine telomere dynamics and the association between telomere length and productive lifespan
P7 Telomere Length and Aortic Valve Calcification
Genetic Determinants of Telomere Length in African American Youth
Unraveling the causal genes and transcriptomic determinants of human telomere length
Peripartum depression symptom trajectories, telomere length and genotype, and adverse childhood experiences
Telomere Length: Implications for Atherogenesis
Telomere length: how the length makes a difference
Adverse childhood experiences, epigenetics and telomere length variation in childhood and beyond: a systematic review of the literature
Alcohol consumption and leukocyte telomere length
Mathematical modelling of telomere length dynamics
Telomere length and human hippocampal neurogenesis
Genetic predisposition to longer telomere length and risk of childhood, adolescent and adult-onset ependymoma
Bovine telomere dynamics and the association between telomere length and productive lifespan
P7 Telomere Length and Aortic Valve Calcification
Genetic Determinants of Telomere Length in African American Youth
Unraveling the causal genes and transcriptomic determinants of human telomere length
Peripartum depression symptom trajectories, telomere length and genotype, and adverse childhood experiences
Telomere Length: Implications for Atherogenesis
Telomere length: how the length makes a difference
Adverse childhood experiences, epigenetics and telomere length variation in childhood and beyond: a systematic review of the literature
Alcohol consumption and leukocyte telomere length
Mathematical modelling of telomere length dynamics
Telomere length and human hippocampal neurogenesis
Genetic predisposition to longer telomere length and risk of childhood, adolescent and adult-onset ependymoma
Bovine telomere dynamics and the association between telomere length and productive lifespan