Role of FOXM1 and AURKB in regulating keratinocyte function in psoriasis
Objective: This study investigated the effect of forkhead box M1 (FOXM1) and Aurora kinase B (AURKB) on the epidermal function of keratinocytes. Methods: Bioinformatics analysis was used to analyze the co-expression network of FOXM1 and its correlation with AURKB. The expression of FOXM1 and AURKB in tissues and cells was detected by immunofluorescence and real-time quantitative polymerase chain reaction, respectively. HaCaT cells were transfected with si-FOXM1 to knock down FOXM1. Cell proliferation was detected by cell counting kit-8 assay. Cell migration was detected by scratch assay. Cell invasion was detected by the Transwell invasion assay. Cell apoptosis and cell cycle were detected by flow cytometry. Results: FOXM1 and AURKB were positively correlated and highly expressed in psoriatic lesions. After transfection of si-FOXM1, the expression levels of FOXM1 and AURKB genes significantly decreased. The proliferation of HaCaT cells decreased, the apoptosis rate increased significantly, and the proportion of cells in the G1 phase increased significantly, while the proportion of cells in the S phase decreased significantly. The scratch closure of HaCaT cells was reduced, and the number of cell invasions decreased significantly. Conclusion: FOXM1 and AURKB may affect the progression of psoriasis by regulating the proliferation, cell cycle, migration, and invasion of keratinocytes.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Role of FOXM1 and AURKB in regulating keratinocyte function in psoriasis ; volume:19 ; number:1 ; year:2024 ; extent:10
Open medicine ; 19, Heft 1 (2024) (gesamt 10)
- Urheber
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Zhao, Zhaofeng
Cheng, Jie
Hou, Qiang
Zhu, Jian
Chen, Tu
Lu, Sheng
Wu, Guiju
Lv, Hongli
Wu, Xiujuan
- DOI
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10.1515/med-2024-1049
- URN
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urn:nbn:de:101:1-2410011535304.874014939015
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:35 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Zhao, Zhaofeng
- Cheng, Jie
- Hou, Qiang
- Zhu, Jian
- Chen, Tu
- Lu, Sheng
- Wu, Guiju
- Lv, Hongli
- Wu, Xiujuan
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