Role of FOXM1 and AURKB in regulating keratinocyte function in psoriasis
Objective: This study investigated the effect of forkhead box M1 (FOXM1) and Aurora kinase B (AURKB) on the epidermal function of keratinocytes. Methods: Bioinformatics analysis was used to analyze the co-expression network of FOXM1 and its correlation with AURKB. The expression of FOXM1 and AURKB in tissues and cells was detected by immunofluorescence and real-time quantitative polymerase chain reaction, respectively. HaCaT cells were transfected with si-FOXM1 to knock down FOXM1. Cell proliferation was detected by cell counting kit-8 assay. Cell migration was detected by scratch assay. Cell invasion was detected by the Transwell invasion assay. Cell apoptosis and cell cycle were detected by flow cytometry. Results: FOXM1 and AURKB were positively correlated and highly expressed in psoriatic lesions. After transfection of si-FOXM1, the expression levels of FOXM1 and AURKB genes significantly decreased. The proliferation of HaCaT cells decreased, the apoptosis rate increased significantly, and the proportion of cells in the G1 phase increased significantly, while the proportion of cells in the S phase decreased significantly. The scratch closure of HaCaT cells was reduced, and the number of cell invasions decreased significantly. Conclusion: FOXM1 and AURKB may affect the progression of psoriasis by regulating the proliferation, cell cycle, migration, and invasion of keratinocytes.
- Location
-
Deutsche Nationalbibliothek Frankfurt am Main
- Extent
-
Online-Ressource
- Language
-
Englisch
- Bibliographic citation
-
Role of FOXM1 and AURKB in regulating keratinocyte function in psoriasis ; volume:19 ; number:1 ; year:2024 ; extent:10
Open medicine ; 19, Heft 1 (2024) (gesamt 10)
- Creator
-
Zhao, Zhaofeng
Cheng, Jie
Hou, Qiang
Zhu, Jian
Chen, Tu
Lu, Sheng
Wu, Guiju
Lv, Hongli
Wu, Xiujuan
- DOI
-
10.1515/med-2024-1049
- URN
-
urn:nbn:de:101:1-2410011535304.874014939015
- Rights
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
-
15.08.2025, 7:35 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Zhao, Zhaofeng
- Cheng, Jie
- Hou, Qiang
- Zhu, Jian
- Chen, Tu
- Lu, Sheng
- Wu, Guiju
- Lv, Hongli
- Wu, Xiujuan
Other Objects (12)
Surface Plasmon Resonance from Bimetallic Interface in Au–Ag Core–Shell Structure Nanowires
The double-edged sword effects of perceived algorithmic control on platform workers’ service performance
Prostatitis as initial manifestation of Chlamydia psittaci pneumonia diagnosed by metagenome next-generation sequencing: A case report
Celecoxib enhances anticancer effect of cisplatin and induces anoikis in osteosarcoma via PI3K/Akt pathway
A document-level information extraction pipeline for layered cathode materials for sodium-ion batteries
Face repairing based on transfer learning method with fewer training samples: application to a Terracotta Warrior with facial cracks and a Buddha with a broken nose
Factors affecting the determination of iron species in the presence of ferric iron
Systematic identification of transcriptional and post-transcriptional regulations in human respiratory epithelial cells during influenza A virus infection
Dose prediction for cervical cancer VMAT patients with a full-scale 3D-cGAN-based model and the comparison of different input data on the prediction results
Predictive factors for intrathoracic anastomotic leakage and postoperative mortality after esophageal cancer resection
Research on Parallel Task Scheduling Algorithm of SaaS Platform Based on Dynamic Adaptive Particle Swarm Optimization in Cloud Service Environment
Docosahexaenoic Acid Protects Traumatic Brain Injury by Regulating NOX2 Generation via Nrf2 Signaling Pathway
Surface Plasmon Resonance from Bimetallic Interface in Au–Ag Core–Shell Structure Nanowires
The double-edged sword effects of perceived algorithmic control on platform workers’ service performance
Prostatitis as initial manifestation of Chlamydia psittaci pneumonia diagnosed by metagenome next-generation sequencing: A case report
Celecoxib enhances anticancer effect of cisplatin and induces anoikis in osteosarcoma via PI3K/Akt pathway
A document-level information extraction pipeline for layered cathode materials for sodium-ion batteries
Face repairing based on transfer learning method with fewer training samples: application to a Terracotta Warrior with facial cracks and a Buddha with a broken nose
Factors affecting the determination of iron species in the presence of ferric iron
Systematic identification of transcriptional and post-transcriptional regulations in human respiratory epithelial cells during influenza A virus infection
Dose prediction for cervical cancer VMAT patients with a full-scale 3D-cGAN-based model and the comparison of different input data on the prediction results
Predictive factors for intrathoracic anastomotic leakage and postoperative mortality after esophageal cancer resection
Research on Parallel Task Scheduling Algorithm of SaaS Platform Based on Dynamic Adaptive Particle Swarm Optimization in Cloud Service Environment
Docosahexaenoic Acid Protects Traumatic Brain Injury by Regulating NOX2 Generation via Nrf2 Signaling Pathway
Surface Plasmon Resonance from Bimetallic Interface in Au–Ag Core–Shell Structure Nanowires
The double-edged sword effects of perceived algorithmic control on platform workers’ service performance
Prostatitis as initial manifestation of Chlamydia psittaci pneumonia diagnosed by metagenome next-generation sequencing: A case report
Celecoxib enhances anticancer effect of cisplatin and induces anoikis in osteosarcoma via PI3K/Akt pathway
A document-level information extraction pipeline for layered cathode materials for sodium-ion batteries
Face repairing based on transfer learning method with fewer training samples: application to a Terracotta Warrior with facial cracks and a Buddha with a broken nose
Factors affecting the determination of iron species in the presence of ferric iron
Systematic identification of transcriptional and post-transcriptional regulations in human respiratory epithelial cells during influenza A virus infection
Dose prediction for cervical cancer VMAT patients with a full-scale 3D-cGAN-based model and the comparison of different input data on the prediction results
Predictive factors for intrathoracic anastomotic leakage and postoperative mortality after esophageal cancer resection
Research on Parallel Task Scheduling Algorithm of SaaS Platform Based on Dynamic Adaptive Particle Swarm Optimization in Cloud Service Environment