Retracing the evolutionary emergence of thymopoiesis
Abstract: The onset of lymphocyte development in the vertebrate primordial thymus, about 500 million years ago, represents one of the foundational events of the emerging adaptive immune system. Here, we retrace the evolutionary trajectory of thymopoiesis, from early vertebrates to mammals, guided by members of the Foxn1/4 transcription factor gene family, which direct the differentiation of the thymic microenvironment. Molecular engineering in transgenic mice recapitulated a gene duplication event, exon replacements, and altered expression patterns. These changes predictably modified the lymphopoietic characteristics of the thymus, identifying molecular features contributing to conversion of a primordial bipotent lymphoid organ to a tissue specializing in T cell development. The phylogenetic reconstruction associates increasing efficiency of T cell generation with diminishing B cell–generating capacity of the thymus during jawed vertebrate evolution
- Standort
-
Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
-
Online-Ressource
- Sprache
-
Englisch
- Anmerkungen
-
Science advances. - 6, 48 (2020) , eabd9585, ISSN: 2375-2548
- Ereignis
-
Veröffentlichung
- (wo)
-
Freiburg
- (wer)
-
Universität
- (wann)
-
2023
- Urheber
- DOI
-
10.1126/sciadv.abd9585
- URN
-
urn:nbn:de:bsz:25-freidok-1757813
- Rechteinformation
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
-
25.03.2025, 13:52 MEZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Swann, Jeremy B.
- Nusser, Anja
- Morimoto, Ryo
- Nagakubo, Daisuke
- Boehm, Thomas
- Universität
Entstanden
- 2023
Ähnliche Objekte (12)
On the Evolutionary Emergence of Optimism
The mechanisms of psychedelic visionary experiences: hypotheses from evolutionary psychology
Migration, media, and the emergence of pidgin‐ and creole‐based informal epicentres
The evolutionary fate of mitochondrial aminoacyl-tRNA synthetases in amitochondrial organisms
On the emergence of aesthetic illusion : an evolutionary perspective
Von Hayek’s theory of cultural evolution in the light of a simplified model of kaufmann’s general biological evolutionary theory
Economic emergence: An evolutionary economic perspective
Emergence, geography & networks of the Indian IT industry : evolutionary perspectives
Emergence of regulatory networks in simulated evolutionary processes
Emergence of Cooperation in Evolutionary Social Interaction Networks
Explanatory integration and integrated explanations in Darwinian medicine and evolutionary medicine
The role of Pb oxidation state of the precursor in the formation of 2D perovskite microplates
On the Evolutionary Emergence of Optimism
The mechanisms of psychedelic visionary experiences: hypotheses from evolutionary psychology
Migration, media, and the emergence of pidgin‐ and creole‐based informal epicentres
The evolutionary fate of mitochondrial aminoacyl-tRNA synthetases in amitochondrial organisms
On the emergence of aesthetic illusion : an evolutionary perspective
Von Hayek’s theory of cultural evolution in the light of a simplified model of kaufmann’s general biological evolutionary theory
Economic emergence: An evolutionary economic perspective
Emergence, geography & networks of the Indian IT industry : evolutionary perspectives
Emergence of regulatory networks in simulated evolutionary processes
Emergence of Cooperation in Evolutionary Social Interaction Networks
Explanatory integration and integrated explanations in Darwinian medicine and evolutionary medicine
The role of Pb oxidation state of the precursor in the formation of 2D perovskite microplates
On the Evolutionary Emergence of Optimism
The mechanisms of psychedelic visionary experiences: hypotheses from evolutionary psychology
Migration, media, and the emergence of pidgin‐ and creole‐based informal epicentres
The evolutionary fate of mitochondrial aminoacyl-tRNA synthetases in amitochondrial organisms
On the emergence of aesthetic illusion : an evolutionary perspective
Von Hayek’s theory of cultural evolution in the light of a simplified model of kaufmann’s general biological evolutionary theory
Economic emergence: An evolutionary economic perspective
Emergence, geography & networks of the Indian IT industry : evolutionary perspectives
Emergence of regulatory networks in simulated evolutionary processes
Emergence of Cooperation in Evolutionary Social Interaction Networks
Explanatory integration and integrated explanations in Darwinian medicine and evolutionary medicine