Retracing the evolutionary emergence of thymopoiesis
Abstract: The onset of lymphocyte development in the vertebrate primordial thymus, about 500 million years ago, represents one of the foundational events of the emerging adaptive immune system. Here, we retrace the evolutionary trajectory of thymopoiesis, from early vertebrates to mammals, guided by members of the Foxn1/4 transcription factor gene family, which direct the differentiation of the thymic microenvironment. Molecular engineering in transgenic mice recapitulated a gene duplication event, exon replacements, and altered expression patterns. These changes predictably modified the lymphopoietic characteristics of the thymus, identifying molecular features contributing to conversion of a primordial bipotent lymphoid organ to a tissue specializing in T cell development. The phylogenetic reconstruction associates increasing efficiency of T cell generation with diminishing B cell–generating capacity of the thymus during jawed vertebrate evolution
- Location
-
Deutsche Nationalbibliothek Frankfurt am Main
- Extent
-
Online-Ressource
- Language
-
Englisch
- Notes
-
Science advances. - 6, 48 (2020) , eabd9585, ISSN: 2375-2548
- Event
-
Veröffentlichung
- (where)
-
Freiburg
- (who)
-
Universität
- (when)
-
2023
- Creator
- DOI
-
10.1126/sciadv.abd9585
- URN
-
urn:nbn:de:bsz:25-freidok-1757813
- Rights
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
-
25.03.2025, 1:52 PM CET
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Swann, Jeremy B.
- Nusser, Anja
- Morimoto, Ryo
- Nagakubo, Daisuke
- Boehm, Thomas
- Universität
Time of origin
- 2023
Other Objects (12)
On the Evolutionary Emergence of Optimism
The mechanisms of psychedelic visionary experiences: hypotheses from evolutionary psychology
Migration, media, and the emergence of pidgin‐ and creole‐based informal epicentres
The evolutionary fate of mitochondrial aminoacyl-tRNA synthetases in amitochondrial organisms
On the emergence of aesthetic illusion : an evolutionary perspective
Economic emergence: An evolutionary economic perspective
Emergence, geography & networks of the Indian IT industry : evolutionary perspectives
Emergence of regulatory networks in simulated evolutionary processes
Emergence of Cooperation in Evolutionary Social Interaction Networks
Von Hayek’s theory of cultural evolution in the light of a simplified model of kaufmann’s general biological evolutionary theory
Evolutionary emergence and diversification of homo-oligomeric protein complexes
Explanatory integration and integrated explanations in Darwinian medicine and evolutionary medicine
On the Evolutionary Emergence of Optimism
The mechanisms of psychedelic visionary experiences: hypotheses from evolutionary psychology
Migration, media, and the emergence of pidgin‐ and creole‐based informal epicentres
The evolutionary fate of mitochondrial aminoacyl-tRNA synthetases in amitochondrial organisms
On the emergence of aesthetic illusion : an evolutionary perspective
Economic emergence: An evolutionary economic perspective
Emergence, geography & networks of the Indian IT industry : evolutionary perspectives
Emergence of regulatory networks in simulated evolutionary processes
Emergence of Cooperation in Evolutionary Social Interaction Networks
Von Hayek’s theory of cultural evolution in the light of a simplified model of kaufmann’s general biological evolutionary theory
Evolutionary emergence and diversification of homo-oligomeric protein complexes
Explanatory integration and integrated explanations in Darwinian medicine and evolutionary medicine
On the Evolutionary Emergence of Optimism
The mechanisms of psychedelic visionary experiences: hypotheses from evolutionary psychology
Migration, media, and the emergence of pidgin‐ and creole‐based informal epicentres
The evolutionary fate of mitochondrial aminoacyl-tRNA synthetases in amitochondrial organisms
On the emergence of aesthetic illusion : an evolutionary perspective
Economic emergence: An evolutionary economic perspective
Emergence, geography & networks of the Indian IT industry : evolutionary perspectives
Emergence of regulatory networks in simulated evolutionary processes
Emergence of Cooperation in Evolutionary Social Interaction Networks
Von Hayek’s theory of cultural evolution in the light of a simplified model of kaufmann’s general biological evolutionary theory
Evolutionary emergence and diversification of homo-oligomeric protein complexes