Lymphocyte pathway analysis using naturally lymphocyte‐deficient fish
Abstract: Comparative phylogenetic analyses are of potential value to establish the essential components of genetic networks underlying physiological traits. For species that naturally lack particular lymphocyte lineages, we show here that this strategy readily distinguishes trait-specific actors from pleiotropic components of the genetic network governing lymphocyte differentiation. Previously, three of the four members of the DNA polymerase X family have been implicated in the junctional diversification process during the somatic assembly of antigen receptors. Our phylogenetic analysis indicates that the presence of terminal deoxynucleotidyl transferase is strictly associated with the facility of V(D)J recombination, whereas PolL and PolM genes are retained even in species lacking Rag-mediated somatic diversification of antigen receptor genes
- Location
-
Deutsche Nationalbibliothek Frankfurt am Main
- Extent
-
Online-Ressource
- Language
-
Englisch
- Notes
-
European journal of immunology. - 53, 12 (2023) , 2350577, ISSN: 1521-4141
- Classification
-
Medizin, Gesundheit
- Event
-
Veröffentlichung
- (where)
-
Freiburg
- (who)
-
Universität
- (when)
-
2023
- Creator
- DOI
-
10.1002/eji.202350577
- URN
-
urn:nbn:de:bsz:25-freidok-2388411
- Rights
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
-
15.08.2025, 7:32 AM CEST
Data provider
This object is provided by:
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Zhang, Gaoqun
- Swann, Jeremy B.
- Felder, Marius
- O’Meara, Connor P.
- Boehm, Thomas
- Universität
Time of origin
- 2023
Other Objects (12)
Lymphocyte pathway analysis using naturally lymphocyte‐deficient fish
Typisierung menschlicher Leukämien durch Analyse des DNA-Arrangements von Immunglobulingenen, T-Zellrezeptorgenen und zellulären Onkogenen
Die Beziehung zwischen der enzymatischen Methylierung und der Transkription der DNA im Maus P815 Mastocytom [Maus-P-Mastocytom]
Co-evolution of a primordial peptide-presentation system and cellular immunity
Oncogenes and human cancer, blood groups in cancer, copper and inflammation, human insulin
Thymic medullary epithelial cell differentiation, thymocyte emigration, and the control of autoimmunity require lympho-epithelial crosstalk via LTßR
Lymphocyte-specific function of the DNA polymerase epsilon subunit Pole3 revealed bynNeomorphic alleles
Thymic development and selection of T lymphocytes
Formation of a functional thymus initiated by a postnatal epithelial progenitor cell
The evolutionary history of lymphoid organs
MHC I tetramer staining tends to overestimate the number of functionally relevant self‐reactive CD8 T cells in the preimmune repertoire
Die Beziehung der enzymatischen Methylierung invers repetitiver DNA Sequenzen zur Transkription in Maus P815 Mastocytoma Zellen
Lymphocyte pathway analysis using naturally lymphocyte‐deficient fish
Typisierung menschlicher Leukämien durch Analyse des DNA-Arrangements von Immunglobulingenen, T-Zellrezeptorgenen und zellulären Onkogenen
Die Beziehung zwischen der enzymatischen Methylierung und der Transkription der DNA im Maus P815 Mastocytom [Maus-P-Mastocytom]
Co-evolution of a primordial peptide-presentation system and cellular immunity
Oncogenes and human cancer, blood groups in cancer, copper and inflammation, human insulin
Thymic medullary epithelial cell differentiation, thymocyte emigration, and the control of autoimmunity require lympho-epithelial crosstalk via LTßR
Lymphocyte-specific function of the DNA polymerase epsilon subunit Pole3 revealed bynNeomorphic alleles
Thymic development and selection of T lymphocytes
Formation of a functional thymus initiated by a postnatal epithelial progenitor cell
The evolutionary history of lymphoid organs
MHC I tetramer staining tends to overestimate the number of functionally relevant self‐reactive CD8 T cells in the preimmune repertoire
Die Beziehung der enzymatischen Methylierung invers repetitiver DNA Sequenzen zur Transkription in Maus P815 Mastocytoma Zellen
Lymphocyte pathway analysis using naturally lymphocyte‐deficient fish
Typisierung menschlicher Leukämien durch Analyse des DNA-Arrangements von Immunglobulingenen, T-Zellrezeptorgenen und zellulären Onkogenen
Die Beziehung zwischen der enzymatischen Methylierung und der Transkription der DNA im Maus P815 Mastocytom [Maus-P-Mastocytom]
Co-evolution of a primordial peptide-presentation system and cellular immunity
Oncogenes and human cancer, blood groups in cancer, copper and inflammation, human insulin
Thymic medullary epithelial cell differentiation, thymocyte emigration, and the control of autoimmunity require lympho-epithelial crosstalk via LTßR
Lymphocyte-specific function of the DNA polymerase epsilon subunit Pole3 revealed bynNeomorphic alleles
Thymic development and selection of T lymphocytes
Formation of a functional thymus initiated by a postnatal epithelial progenitor cell
The evolutionary history of lymphoid organs
MHC I tetramer staining tends to overestimate the number of functionally relevant self‐reactive CD8 T cells in the preimmune repertoire