Rapid and stable mobilization of CD8+ T cells by SARS-CoV-2 mRNA vaccine

Abstract: SARS-CoV-2 spike mRNA vaccines1,2,3 mediate protection from severe disease as early as ten days after prime vaccination3, when neutralizing antibodies are hardly detectable4,5,6. Vaccine-induced CD8+ T cells may therefore be the main mediators of protection at this early stage7,8. The details of their induction, comparison to natural infection, and association with other arms of vaccine-induced immunity remain, however, incompletely understood. Here we show on a single-epitope level that a stable and fully functional CD8+ T cell response is vigorously mobilized one week after prime vaccination with bnt162b2, when circulating CD4+ T cells and neutralizing antibodies are still weakly detectable. Boost vaccination induced a robust expansion that generated highly differentiated effector CD8+ T cells; however, neither the functional capacity nor the memory precursor T cell pool was affected. Compared with natural infection, vaccine-induced early memory T cells exhibited similar functional capacities but a different subset distribution. Our results indicate that CD8+ T cells are important effector cells, are expanded in the early protection window after prime vaccination, precede maturation of other effector arms of vaccine-induced immunity and are stably maintained after boost vaccination

Angaben zum Objekt

• Standort: Deutsche Nationalbibliothek Frankfurt am Main
• Umfang: Online-Ressource
• Sprache: Englisch
• Anmerkungen: Nature. - 597, 7875 (2021) , 268-273, ISSN: 1476-4687

Beteiligte, Orts- und Zeitangaben

• Ereignis: Veröffentlichung
• (wo): Freiburg
• (wer): Universität
• (wann): 2021
• Urheber: Oberhardt, Valerie ; Luxenburger, Hendrik ; Kemming, Janine ; Schulien, Isabel ; Ciminski, Kevin ; Giese, Sebastian ; Csernalabics, Benedikt ; Lang-Meli, Julia ; Janowska, Iga ; Staniek, Julian ; Wild, Katharina ; Basho, Kristi ; Marinescu, Mircea Stefan ; Fuchs, Jonas ; Topfstedt, Fernando ; Janda, Ales̆ ; Sogukpinar, Özlem ; Hilger, Hanna ; Stete, Katarina ; Emmerich, Florian ; Bengsch, Bertram ; Waller, Cornelius ; Rieg, Siegbert ; Sagar, Stephen ; Böttler, Tobias ; Zoldan, Martina Katharina ; Kochs, Georg ; Schwemmle, Martin ; Rizzi, Marta ; Thimme, Robert ; Neumann-Haefelin, Christoph ; Hofmann, Maike

Weitere Informationen

• DOI: 10.1038/s41586-021-03841-4
• URN: urn:nbn:de:bsz:25-freidok-2199248
• Rechteinformation: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Letzte Aktualisierung: 25.03.2025, 13:48 MEZ