Synthesis of (−)-(R)-sitagliptin by RhI-catalyzed asymmetric hydroamination
Abstract: We report of a concise synthesis of (R)-sitagliptin monophosphate – a drug predominantly applied in the treatment of type 2 diabetes. Utilizing our recently developed RhI-catalyzed hydroamination of allenes for the stereoselective construction of the inherent chiral amino function, a new approach to (R)-sitagliptin monophosphate on a 3.5 mmol scale was established
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Anmerkungen
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European journal of organic chemistry. - 2021, 46 (2021) , 6247-6249, ISSN: 1099-0690
- Ereignis
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Veröffentlichung
- (wo)
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Freiburg
- (wer)
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Universität
- (wann)
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2021
- Urheber
- DOI
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10.1002/ejoc.202100832
- URN
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urn:nbn:de:bsz:25-freidok-2231177
- Rechteinformation
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Kein Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:19 MESZ
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Beteiligte
- Berthold, Dino
- Breit, Bernhard
- Universität
Entstanden
- 2021
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