Role and inhibition of Src signaling in the progression of liver cancer

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Abstract: During 2012, about 782,500 new liver cancer cases were diagnosed and 745,500 deaths occurred all around the world. Liver cancer is the 2nd major cause of cancer death in men around the world and in underdeveloped countries. Dysregulation of the balance between proliferation and cell death, hepatitis B virus infection and hepatitis C virus chronic infection, and carcinogenic micro RNAs mainly contribute to the development and progression of liver cancer. Under physiological status, Src maintained the foundation of cells. While in liver cancer, it is known that the basic activities of cells are apparently disturbed possibly by Src. The mechanisms underlying the development and progression of liver cancer is needed to elucidate. In this study, we summarized newly found regulation pathway of SRC signaling, and clinical experience with inhibitors of Src signaling, such as, novel molecules that directly or indirectly targeted Src signaling which can be utilized in the treatment of liver cancer.

Standort: Deutsche Nationalbibliothek Frankfurt am Main

Umfang: Online-Ressource

Sprache: Englisch

Erschienen in: Role and inhibition of Src signaling in the progression of liver cancer ; volume:11 ; number:1 ; year:2016 ; pages:513-518 ; extent:6
Open life sciences ; 11, Heft 1 (2016), 513-518 (gesamt 6)

Urheber: Ren, Hong
Fang, Jie
Ding, Xianjun
Chen, Qiyun

DOI: 10.1515/biol-2016-0067

URN: urn:nbn:de:101:1-2409201636321.476707033397

Rechteinformation: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.

Letzte Aktualisierung: 15.08.2025, 07:34 MESZ

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Beteiligte

Ren, Hong
Fang, Jie
Ding, Xianjun
Chen, Qiyun

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Role and inhibition of Src signaling in the progression of liver cancer

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Ähnliche Objekte (12)

AC-93253 iodide, a novel Src inhibitor, suppresses NSCLC progression by modulating multiple Src-related signaling pathways

SRC-RAC1 signaling drives drug resistance to BRAF inhibition in de-differentiated cutaneous melanomas

Src kinase inhibition promotes the chondrocyte phenotype

SRC inhibition prevents P-cadherin mediated signaling and function in basal-like breast cancer cells

CXCR7 promotes melanoma tumorigenesis via Src kinase signaling

Src signaling in a low-complexity unicellular kinome

The Src family kinases: distinct functions of c-Src, Yes, and Fyn in the liver

RNA-binding protein RPS7 promotes hepatocellular carcinoma progression via LOXL2-dependent activation of ITGB1/FAK/SRC signaling

v-Src-driven transformation is due to chromosome abnormalities but not Src-mediated growth signaling

Estrogen modulates serotonin effects on vasoconstriction through Src inhibition

Ropivacaine attenuates endotoxin plus hyperinflation-mediated acute lung injury via inhibition of early-onset Src-dependent signaling

Correction: RNA-binding protein RPS7 promotes hepatocellular carcinoma progression via LOXL2-dependent activation of ITGB1/FAK/SRC signaling

AC-93253 iodide, a novel Src inhibitor, suppresses NSCLC progression by modulating multiple Src-related signaling pathways

SRC-RAC1 signaling drives drug resistance to BRAF inhibition in de-differentiated cutaneous melanomas

Src kinase inhibition promotes the chondrocyte phenotype

SRC inhibition prevents P-cadherin mediated signaling and function in basal-like breast cancer cells

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Src signaling in a low-complexity unicellular kinome

The Src family kinases: distinct functions of c-Src, Yes, and Fyn in the liver

RNA-binding protein RPS7 promotes hepatocellular carcinoma progression via LOXL2-dependent activation of ITGB1/FAK/SRC signaling

v-Src-driven transformation is due to chromosome abnormalities but not Src-mediated growth signaling

Estrogen modulates serotonin effects on vasoconstriction through Src inhibition

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Correction: RNA-binding protein RPS7 promotes hepatocellular carcinoma progression via LOXL2-dependent activation of ITGB1/FAK/SRC signaling

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v-Src-driven transformation is due to chromosome abnormalities but not Src-mediated growth signaling

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