Methods for the synthesis of xanthine-derived polycyclic fused systems

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Abstract: Xanthines are a widely known group of alkaloids, commonly used as bronchodilators and psycho and cardiac stimulants. Most of their actions are principally connected with either antagonism of adenosine receptors or phosphodiesterase inhibition; nevertheless, other profiles of their biological activity – antiviral, antitumor or anticancer – are also known. Here, we present a review of the main synthetic methods to obtain xanthine-derived heterocyclic fused systems. The five-, six- or seven-membered heterocyclic ring is attached to the purine-2,6-dione core with one or two bridgehead (ring junction) nitrogen atoms. The biological activity profile of the individual heterocyclic systems is mentioned.

Location: Deutsche Nationalbibliothek Frankfurt am Main

Extent: Online-Ressource

Language: Englisch

Bibliographic citation: Methods for the synthesis of xanthine-derived polycyclic fused systems ; volume:19 ; number:5 ; year:2013 ; pages:297-310
Heterocyclic communications ; 19, Heft 5 (2013), 297-310

Creator: Szymańska, Ewa
Mazurkiewicz, Jakub
Kieć-Kononowicz, Katarzyna

DOI: 10.1515/hc-2013-0082

URN: urn:nbn:de:101:1-2501130536361.588211349004

Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 15.08.2025, 7:23 AM CEST

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Szymańska, Ewa
Mazurkiewicz, Jakub
Kieć-Kononowicz, Katarzyna

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Methods for the synthesis of xanthine-derived polycyclic fused systems

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