Photocatalytic Synthesis of Polycyclic Indolones
Abstract: In this work, a photocatalytic strategy for a rapid and modular access to polycyclic indolones starting from readily available indoles is reported. This strategy relies on the use of redox‐active esters in combination with an iridium‐based photocatalyst under visible‐light irradiation. The generation of alkyl radicals through decarboxylative single electron reductions enables intramolecular homolytic aromatic substitutions with a pending indole moiety to afford pyrrolo‐ and pyridoindolone derivatives under mild conditions. Furthermore, it was demonstrated that these radicals could also be engaged into cascades consisting of an intermolecular Giese‐type addition followed by an intramolecular homolytic aromatic substitution to rapidly assemble valuable azepinoindolones.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Photocatalytic Synthesis of Polycyclic Indolones ; volume:26 ; number:31 ; year:2020 ; pages:7004-7007 ; extent:4
Chemistry - a European journal ; 26, Heft 31 (2020), 7004-7007 (gesamt 4)
- Creator
- DOI
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10.1002/chem.202001324
- URN
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urn:nbn:de:101:1-2022060516104802763316
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:35 AM CEST
Data provider
This object is provided by:
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Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Saget, Tanguy
- König, Burkhard
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