The Direct Electrochemical Detection of Hepatitis B Virus

Abstract: The direct electrochemistry of hepatitis B virus containing the covalently closed circular DNA (HBV cccDNA) is realized at pretreated glassy carbon electrode (PGCE). It is essential that the direct electron transfer of guanine (G) and adenine (A) on HBV cccDNA strand is captured by microwave irradiation to melt cccDNA into ssDNA. The irreversible adsorption and diffusion controlled processes of G and A are revealed by cyclic voltammetry with participating 2 protons and 2 electrons respectively. In addition, we found that there are two oxidation peaks of G and A in whole blood containing HBV. Nevertheless, there is only one oxidation peak of G in whole blood of normal people. According to this difference of oxidation peaks in whole blood sample, it can be used screen quickly HBV infection or carriers in clinic and large area of blood donors.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: The Direct Electrochemical Detection of Hepatitis B Virus ; day:27 ; month:07 ; year:2023 ; extent:10 ; ChemElectroChem ; (27.07.2023) (gesamt 10)

Contributors, Places and Time

• Creator: Xu, Jiawen ; Wang, Yufei ; Sha, Zhou ; Chen, Yanpei ; Sun, Changjiang ; Gu, Hai‐Ying

Further information

• DOI: 10.1002/celc.202300154
• URN: urn:nbn:de:101:1-2023072815085351312915
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 14.08.2025, 10:54 AM CEST