DNA‐Encoded Libraries and Their Application to RNA

Abstract: The functional roles of structured RNAs in the regulation of biological processes, and hence RNA's potential as an effective therapeutic target, have only recently been appreciated. Robust and high‐throughput methods that identify potent RNA ligands are critical to the development of chemical probes and therapeutics. DNA‐encoded libraries (DEL) technology has emerged as a powerful tool for protein ligand discovery, and its ability to generate large, custom‐tailored, and novel chemical space offers unprecedented opportunities to discover the rules of RNA ligand design. In this review, we discuss the basic principles of DEL selection, current progress on the application of DEL to RNA targets, and the outlook of targeting RNA by DEL.

Standort
Deutsche Nationalbibliothek Frankfurt am Main
Umfang
Online-Ressource
Sprache
Englisch

Erschienen in
DNA‐Encoded Libraries and Their Application to RNA ; day:10 ; month:07 ; year:2023 ; extent:13
Israel journal of chemistry ; (10.07.2023) (gesamt 13)

Urheber
Yang, Xueyi
Childs‐Disney, Jessica L.
Paegel, M.
Disney, Matthew D.

DOI
10.1002/ijch.202300073
URN
urn:nbn:de:101:1-2023071115024773771780
Rechteinformation
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
Letzte Aktualisierung
14.08.2025, 10:55 MESZ

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Beteiligte

  • Yang, Xueyi
  • Childs‐Disney, Jessica L.
  • Paegel, M.
  • Disney, Matthew D.

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