DNA‐Encoded Libraries and Their Application to RNA
Abstract: The functional roles of structured RNAs in the regulation of biological processes, and hence RNA's potential as an effective therapeutic target, have only recently been appreciated. Robust and high‐throughput methods that identify potent RNA ligands are critical to the development of chemical probes and therapeutics. DNA‐encoded libraries (DEL) technology has emerged as a powerful tool for protein ligand discovery, and its ability to generate large, custom‐tailored, and novel chemical space offers unprecedented opportunities to discover the rules of RNA ligand design. In this review, we discuss the basic principles of DEL selection, current progress on the application of DEL to RNA targets, and the outlook of targeting RNA by DEL.
- Standort
-
Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
-
Online-Ressource
- Sprache
-
Englisch
- Erschienen in
-
DNA‐Encoded Libraries and Their Application to RNA ; day:10 ; month:07 ; year:2023 ; extent:13
Israel journal of chemistry ; (10.07.2023) (gesamt 13)
- Urheber
-
Yang, Xueyi
Childs‐Disney, Jessica L.
Paegel, M.
Disney, Matthew D.
- DOI
-
10.1002/ijch.202300073
- URN
-
urn:nbn:de:101:1-2023071115024773771780
- Rechteinformation
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
-
14.08.2025, 10:55 MESZ
Datenpartner
Dieses Objekt wird bereitgestellt von:
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Yang, Xueyi
- Childs‐Disney, Jessica L.
- Paegel, M.
- Disney, Matthew D.
Ähnliche Objekte (12)
DNA-encoded libraries
DNA-encoded dynamic combinatorial chemical libraries
Computational methodologies for DNA-encoded libraries
Scanning protein surfaces with DNA-encoded libraries
Scanning Protein Surfaces with DNA‐Encoded Libraries
Development of synthesis methodology for DNA-encoded libraries
On‐DNA Transfer Hydrogenolysis and Hydrogenation for the Synthesis of DNA‐Encoded Chemical Libraries
On‐DNA Transfer Hydrogenolysis and Hydrogenation for the Synthesis of DNA‐Encoded Chemical Libraries
The Potential of Micellar Media in the Synthesis of DNA‐Encoded Libraries
DNA-encoded libraries – an efficient small molecule discovery technology for the biomedical sciences
DNA‐Encoded Libraries: Aryl Fluorosulfonates as Versatile Electrophiles Enabling Facile On‐DNA Suzuki, Sonogashira, and Buchwald Reactions
sp 3 ‐Rich Heterocycle Synthesis on DNA: Application to DNA‐Encoded Library Production
DNA-encoded libraries
DNA-encoded dynamic combinatorial chemical libraries
Computational methodologies for DNA-encoded libraries
Scanning protein surfaces with DNA-encoded libraries
Scanning Protein Surfaces with DNA‐Encoded Libraries
Development of synthesis methodology for DNA-encoded libraries
On‐DNA Transfer Hydrogenolysis and Hydrogenation for the Synthesis of DNA‐Encoded Chemical Libraries
On‐DNA Transfer Hydrogenolysis and Hydrogenation for the Synthesis of DNA‐Encoded Chemical Libraries
The Potential of Micellar Media in the Synthesis of DNA‐Encoded Libraries
DNA-encoded libraries – an efficient small molecule discovery technology for the biomedical sciences
DNA‐Encoded Libraries: Aryl Fluorosulfonates as Versatile Electrophiles Enabling Facile On‐DNA Suzuki, Sonogashira, and Buchwald Reactions
sp 3 ‐Rich Heterocycle Synthesis on DNA: Application to DNA‐Encoded Library Production
DNA-encoded libraries
DNA-encoded dynamic combinatorial chemical libraries
Computational methodologies for DNA-encoded libraries
Scanning protein surfaces with DNA-encoded libraries
Scanning Protein Surfaces with DNA‐Encoded Libraries
Development of synthesis methodology for DNA-encoded libraries
On‐DNA Transfer Hydrogenolysis and Hydrogenation for the Synthesis of DNA‐Encoded Chemical Libraries
On‐DNA Transfer Hydrogenolysis and Hydrogenation for the Synthesis of DNA‐Encoded Chemical Libraries
The Potential of Micellar Media in the Synthesis of DNA‐Encoded Libraries
DNA-encoded libraries – an efficient small molecule discovery technology for the biomedical sciences
DNA‐Encoded Libraries: Aryl Fluorosulfonates as Versatile Electrophiles Enabling Facile On‐DNA Suzuki, Sonogashira, and Buchwald Reactions