Catalytic Synthesis of Trifluoromethyl Cyclopropenes and Oligo‐Cyclopropenes †
Abstract: The synthesis of trifluoromethylated cyclopropenes is often associated with important applications in drug discovery and functional materials. In this report, we describe the use of readily available chiral rhodium (II) catalysts for a highly efficient asymmetric cyclopropenation reaction of fluorinated donor–acceptor diazoalkanes with a broad variety of aliphatic and aromatic alkynes. Further studies highlight the unique reactivity of fluorinated donor–acceptor diazoalkanes in the synthesis of oligo‐cyclopropenes. Subsequent C−H functionalization of trifluoromethyl cyclopropenes furnishes densely substituted cyclopropene frameworks and also allows the alternative synthesis of bis‐cyclopropenes.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Catalytic Synthesis of Trifluoromethyl Cyclopropenes and Oligo‐Cyclopropenes † ; volume:26 ; number:6 ; year:2020 ; pages:1254-1257 ; extent:4
Chemistry - a European journal ; 26, Heft 6 (2020), 1254-1257 (gesamt 4)
- Creator
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Tran, Uyen P. N.
Hommelsheim, Renè
Yang, Zhen
Empel, Claire
Hock, Katharina J.
Nguyen, Thanh V.
Koenigs, Rene M.
- DOI
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10.1002/chem.201904680
- URN
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urn:nbn:de:101:1-2022060307364192117774
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:27 AM CEST
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Associated
- Tran, Uyen P. N.
- Hommelsheim, Renè
- Yang, Zhen
- Empel, Claire
- Hock, Katharina J.
- Nguyen, Thanh V.
- Koenigs, Rene M.
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