A prospective non-interventional study on the impact of transfusion burden and related iron toxicity on outcome in myelodysplastic syndromes undergoing allogeneic hematopoietic cell transplantation
Abstract: Most myelodysplastic syndromes (MDS)-patients receive multiple red blood cell transfusions (RBCT). Transfusions may cause iron-related toxicity and mortality, influencing outcome after allogeneic HSCT. This prospective non-interventional study evaluated 222 MDS and CMML patients undergoing HSCT. Overall survival (OS), relapse-free survival (RFS), non-relapse mortality (NRM), and relapse incidence (RI) at 36 months were 52%, 44%, 25%, and 31%, respectively. Age, percentage of marrow blasts and severe comorbidities impacted OS. RFS was significantly associated with RBCT burden prior to HSCT (HR: 1.7; p = .02). High ferritin levels had a significant negative impact on OS and RI, but no impact on NRM. Administration of iron chelation therapy prior to HSCT did not influence the outcome, but early iron reduction after HSCT (started before 6 months) improved RFS significantly after transplantation (56% in the control group vs. 90% in the treated group, respectively; p = .04). This study illustrates the impact of RBCT and related parameters on HSCT-outcome. Patients with an expected prolonged survival after transplantation may benefit from early iron reduction therapy after transplantation
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Anmerkungen
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Leukemia & lymphoma. - 60, 10 (2019) , 2404-2414, ISSN: 1029-2403
- Schlagwort
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Chelattherapie
Bluttransfusion
Myelodysplastisches Syndrom
- Ereignis
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Veröffentlichung
- (wo)
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Freiburg
- (wer)
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Universität
- (wann)
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2019
- Urheber
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Cremers, Eline M. P.
Witte, Theo de
Wreede, Liesbeth Cornelia de
Eikema, Diderik-Jan
Köster, Linda
Biezen, Anja van
Finke, Jürgen
Socié, Gerard
Beelen, Dietrich W.
Maertens, Johan
Nagler, Arnon
Kobbe, Guido
Ziagkos, Dimitris
Itälä‐Remes, Maija
Gedde-Dahl, Tobias
Sierra, Jorge
Niederwieser, Dietger
Ljungman, Per
Beguin, Yves
Ozkurt, Zubeyde Nur
Anagnostopoulos, Achilles
Jindra, Pavel
Robin, Marie
Kröger, Nicolaus
- DOI
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10.1080/10428194.2019.1594215
- URN
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urn:nbn:de:bsz:25-freidok-1512854
- Rechteinformation
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Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
-
14.08.2025, 10:51 MESZ
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Beteiligte
- Cremers, Eline M. P.
- Witte, Theo de
- Wreede, Liesbeth Cornelia de
- Eikema, Diderik-Jan
- Köster, Linda
- Biezen, Anja van
- Finke, Jürgen
- Socié, Gerard
- Beelen, Dietrich W.
- Maertens, Johan
- Nagler, Arnon
- Kobbe, Guido
- Ziagkos, Dimitris
- Itälä‐Remes, Maija
- Gedde-Dahl, Tobias
- Sierra, Jorge
- Niederwieser, Dietger
- Ljungman, Per
- Beguin, Yves
- Ozkurt, Zubeyde Nur
- Anagnostopoulos, Achilles
- Jindra, Pavel
- Robin, Marie
- Kröger, Nicolaus
- Universität
Entstanden
- 2019
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