Hochschulschrift
Untersuchungen zur antibakteriellen Wirkung senfölhaltiger Pflanzenstoffe auf uropathogene Infektionserreger
Zusammenfassung: The common use of antibiotics even in cases of mild bacterial infection is associated with the spread of resistant and even multi-resistant pathogens. Subsequently, alternative treatment options need to be evaluated. Isothiocyanates (ITC) have been discussed as an alternative treatment strategy for uncomplicated bacterial cystitis, recently. In this in vitro study, we tested the susceptibility of clinical isolates of uropathogenic E. coli (UPEC) to native plant products as well as synthetic ITC. We also assessed a possible influence of antibiotic resistance on ITC susceptibility. As a result we found potent antimicrobial efficiency of native plant products as well as synthetic ITC against UPEC in vitro. Multi-drug resistant strains thereby showed reduced susceptibility to ITC. Future studies need to conclusively evaluate if sufficient concentrations of ITC can indeed be reached in vivo. Furthermore, the reason for a reduced ITC-susceptibility in multi-drug resistant strains is unknown. Similar mechanisms of action in ITC and conventional antibiotic agents or an efficiency of existing mechanisms of antibiotic resistance against ITC are possible. Further evaluation might lead to a better understanding of the molecular mechanisms behind the antimicrobial effect of ITC
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Deutsch
- Anmerkungen
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Albert-Ludwigs-Universität Freiburg, Dissertation, 2016
- Schlagwort
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Pflanzeninhaltsstoff
Isothiocyanate
Harnwegsinfektion
Multidrug-Resistenz
Urologie
Urogenitalkrankheit
Harnwegskrankheit
- Ereignis
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Veröffentlichung
- (wo)
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Freiburg
- (wer)
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Universität
- (wann)
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2016
- Urheber
- Beteiligte Personen und Organisationen
- DOI
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10.6094/UNIFR/11093
- URN
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urn:nbn:de:bsz:25-freidok-110936
- Rechteinformation
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Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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14.08.2025, 10:55 MESZ
Datenpartner
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Objekttyp
- Hochschulschrift
Beteiligte
- Mampel, Anja
- Frank, Uwe
- Universität
Entstanden
- 2016