Solvent‐ and Catalyst‐Free Aza‐Michael Addition of Imidazoles and Related Heterocycles †

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This work demonstrates the scope and limitations of the aza‐Michael addition of imidazoles and related heterocycles with electron deficient olefins under solvent‐ and catalyst‐free conditions. The reaction proceeds at 80 °C within hours towards completion as long as the azole derivative is sufficiently soluble in the Michael acceptor, which has been used in small excess. Workup only comprises evaporation of surplus Michael‐acceptor, and no additional solvents are necessary for purifying the products.

Location: Deutsche Nationalbibliothek Frankfurt am Main

Extent: Online-Ressource

Language: Englisch

Bibliographic citation: Solvent‐ and Catalyst‐Free Aza‐Michael Addition of Imidazoles and Related Heterocycles † ; volume:2020 ; number:19 ; year:2020 ; pages:2973-2978 ; extent:6
European journal of organic chemistry ; 2020, Heft 19 (2020), 2973-2978 (gesamt 6)

Creator: Kodolitsch, Katharina
Gobec, Florian
Slugovc, Christian

DOI: 10.1002/ejoc.202000309

URN: urn:nbn:de:101:1-2022062613532497029798

Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 15.08.2025, 7:28 AM CEST

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Kodolitsch, Katharina
Gobec, Florian
Slugovc, Christian

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Solvent‐ and Catalyst‐Free Aza‐Michael Addition of Imidazoles and Related Heterocycles †

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