Synthetic Approaches toward Monocyclic 3‐Amino‐β‐lactams
Abstract: Due to the emerging resistance against classical β‐lactam‐based antibiotics, a growing number of bacterial infections has become harder to treat. This alarming tendency necessitates continued research on novel antibacterial agents. Many classes of β‐lactam antibiotics are characterized by the presence of the 3‐aminoazetidin‐2‐one core, which resembles the natural substrate of the target penicillin‐binding proteins. In that respect, this Review summarizes the different synthetic pathways toward this key structure for the development of new antibacterial agents. The most extensively applied methods for 3‐amino‐β‐lactam ring formation are discussed, in addition to a few less common strategies. Moreover, approaches to introduce the 3‐amino substituent after ring formation are also covered.
- Standort
-
Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
-
Online-Ressource
- Sprache
-
Englisch
- Erschienen in
-
Synthetic Approaches toward Monocyclic 3‐Amino‐β‐lactams ; volume:6 ; number:3 ; year:2017 ; pages:301-319 ; extent:19
ChemistryOpen ; 6, Heft 3 (2017), 301-319 (gesamt 19)
- Urheber
-
Deketelaere, Sari
Van Nguyen, Tuyen
Stevens, Christian V.
D'hooghe, Matthias
- DOI
-
10.1002/open.201700051
- URN
-
urn:nbn:de:101:1-2022100606091062135930
- Rechteinformation
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
-
15.08.2025, 07:21 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Deketelaere, Sari
- Van Nguyen, Tuyen
- Stevens, Christian V.
- D'hooghe, Matthias
Ähnliche Objekte (12)
![New routes to enantiopure β2-amino [beta two amino] acids : (dynamic) kinetic resolution of oxazinones and β-lactams [beta lactams]](/assets/placeholder/searchResultMediaNoDigitisedMedia.png)
New routes to enantiopure β2-amino [beta two amino] acids : (dynamic) kinetic resolution of oxazinones and β-lactams [beta lactams]
![Synthesis of new spirocyclopropanated β-lactams [beta-lactams] and their application as building blocks for β-amino [beta-amino] acid peptides](/assets/placeholder/searchResultMediaUnknown.png)
Synthesis of new spirocyclopropanated β-lactams [beta-lactams] and their application as building blocks for β-amino [beta-amino] acid peptides
An Expeditious Synthesis Of 3-Amino B-Lactams Derived From Polyaromatic Compounds
Enzymatic C–H Amidation toward Stereoselective Construction of β-, γ- and δ-Lactams
A Convenient Synthesis of Some Phenyl‐Substituted Aliyclic β‐Amino Esters and β‐Lactams
Toward Synthetic Physical Fingerprint Targets
Toward Synthetic Physical Fingerprint Targets
Synthetic study toward tridachiapyrone B
Biocatalytic, Enantioselective Synthesis of Lactams
Synthetic study toward the diterpenoid aberrarone
Synthetic approaches to multifunctional indenes
The organic chemistry of β-lactams
New routes to enantiopure β2-amino [beta two amino] acids : (dynamic) kinetic resolution of oxazinones and β-lactams [beta lactams]
Synthesis of new spirocyclopropanated β-lactams [beta-lactams] and their application as building blocks for β-amino [beta-amino] acid peptides
An Expeditious Synthesis Of 3-Amino B-Lactams Derived From Polyaromatic Compounds
Enzymatic C–H Amidation toward Stereoselective Construction of β-, γ- and δ-Lactams
A Convenient Synthesis of Some Phenyl‐Substituted Aliyclic β‐Amino Esters and β‐Lactams
Toward Synthetic Physical Fingerprint Targets
Toward Synthetic Physical Fingerprint Targets
Synthetic study toward tridachiapyrone B
Biocatalytic, Enantioselective Synthesis of Lactams
Synthetic study toward the diterpenoid aberrarone
Synthetic approaches to multifunctional indenes
The organic chemistry of β-lactams
New routes to enantiopure β2-amino [beta two amino] acids : (dynamic) kinetic resolution of oxazinones and β-lactams [beta lactams]
Synthesis of new spirocyclopropanated β-lactams [beta-lactams] and their application as building blocks for β-amino [beta-amino] acid peptides
An Expeditious Synthesis Of 3-Amino B-Lactams Derived From Polyaromatic Compounds
Enzymatic C–H Amidation toward Stereoselective Construction of β-, γ- and δ-Lactams
A Convenient Synthesis of Some Phenyl‐Substituted Aliyclic β‐Amino Esters and β‐Lactams
Toward Synthetic Physical Fingerprint Targets
Toward Synthetic Physical Fingerprint Targets
Synthetic study toward tridachiapyrone B
Biocatalytic, Enantioselective Synthesis of Lactams
Synthetic study toward the diterpenoid aberrarone
Synthetic approaches to multifunctional indenes