Synthetic Approaches toward Monocyclic 3‐Amino‐β‐lactams

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Abstract: Due to the emerging resistance against classical β‐lactam‐based antibiotics, a growing number of bacterial infections has become harder to treat. This alarming tendency necessitates continued research on novel antibacterial agents. Many classes of β‐lactam antibiotics are characterized by the presence of the 3‐aminoazetidin‐2‐one core, which resembles the natural substrate of the target penicillin‐binding proteins. In that respect, this Review summarizes the different synthetic pathways toward this key structure for the development of new antibacterial agents. The most extensively applied methods for 3‐amino‐β‐lactam ring formation are discussed, in addition to a few less common strategies. Moreover, approaches to introduce the 3‐amino substituent after ring formation are also covered.

Location: Deutsche Nationalbibliothek Frankfurt am Main

Extent: Online-Ressource

Language: Englisch

Bibliographic citation: Synthetic Approaches toward Monocyclic 3‐Amino‐β‐lactams ; volume:6 ; number:3 ; year:2017 ; pages:301-319 ; extent:19
ChemistryOpen ; 6, Heft 3 (2017), 301-319 (gesamt 19)

Creator: Deketelaere, Sari
Van Nguyen, Tuyen
Stevens, Christian V.
D'hooghe, Matthias

DOI: 10.1002/open.201700051

URN: urn:nbn:de:101:1-2022100606091062135930

Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 15.08.2025, 7:21 AM CEST

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Deketelaere, Sari
Van Nguyen, Tuyen
Stevens, Christian V.
D'hooghe, Matthias

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An Expeditious Synthesis Of 3-Amino B-Lactams Derived From Polyaromatic Compounds

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Synthetic Approaches toward Monocyclic 3‐Amino‐β‐lactams

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Other Objects (12)

New routes to enantiopure β2-amino [beta two amino] acids : (dynamic) kinetic resolution of oxazinones and β-lactams [beta lactams]

Synthesis of new spirocyclopropanated β-lactams [beta-lactams] and their application as building blocks for β-amino [beta-amino] acid peptides

An Expeditious Synthesis Of 3-Amino B-Lactams Derived From Polyaromatic Compounds

Enzymatic C–H Amidation toward Stereoselective Construction of β-, γ- and δ-Lactams

A Convenient Synthesis of Some Phenyl‐Substituted Aliyclic β‐Amino Esters and β‐Lactams

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Biocatalytic, Enantioselective Synthesis of Lactams

Synthetic study toward the diterpenoid aberrarone

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Synthesis of new spirocyclopropanated β-lactams [beta-lactams] and their application as building blocks for β-amino [beta-amino] acid peptides

An Expeditious Synthesis Of 3-Amino B-Lactams Derived From Polyaromatic Compounds

Enzymatic C–H Amidation toward Stereoselective Construction of β-, γ- and δ-Lactams

A Convenient Synthesis of Some Phenyl‐Substituted Aliyclic β‐Amino Esters and β‐Lactams

Toward Synthetic Physical Fingerprint Targets

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Biocatalytic, Enantioselective Synthesis of Lactams

Synthetic study toward the diterpenoid aberrarone

Synthetic approaches to multifunctional indenes

The organic chemistry of β-lactams

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Synthesis of new spirocyclopropanated β-lactams [beta-lactams] and their application as building blocks for β-amino [beta-amino] acid peptides

An Expeditious Synthesis Of 3-Amino B-Lactams Derived From Polyaromatic Compounds

Enzymatic C–H Amidation toward Stereoselective Construction of β-, γ- and δ-Lactams

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