The Synthesis of Primary Amines through Reductive Amination Employing an Iron Catalyst
Abstract: The reductive amination of ketones and aldehydes by ammonia is a highly attractive method for the synthesis of primary amines. The use of catalysts, especially reusable catalysts, based on earth‐abundant metals is similarly appealing. Here, the iron‐catalyzed synthesis of primary amines through reductive amination was realized. A broad scope and a very good tolerance of functional groups were observed. Ketones, including purely aliphatic ones, aryl–alkyl, dialkyl, and heterocyclic, as well as aldehydes could be converted smoothly into their corresponding primary amines. In addition, the amination of pharmaceuticals, bioactive compounds, and natural products was demonstrated. Many functional groups, such as hydroxy, methoxy, dioxol, sulfonyl, and boronate ester substituents, were tolerated. The catalyst is easy to handle, selective, and reusable and ammonia dissolved in water could be employed as the nitrogen source. The key is the use of a specific Fe complex for the catalyst synthesis and an N‐doped SiC material as catalyst support.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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The Synthesis of Primary Amines through Reductive Amination Employing an Iron Catalyst ; volume:13 ; number:12 ; year:2020 ; pages:3110-3114 ; extent:5
ChemSusChem ; 13, Heft 12 (2020), 3110-3114 (gesamt 5)
- Creator
- DOI
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10.1002/cssc.202000856
- URN
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urn:nbn:de:101:1-2022061009232243396032
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:25 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Bäumler, Christoph
- Bauer, Christof
- Kempe, Rhett
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Rhodium‐Catalysed Reductive Amination for the Synthesis of Tertiary Amines
General Synthesis of Alkyl Amines via Borrowing Hydrogen and Reductive Amination
Asymmetric synthesis of γ-branched amines via rhodium-catalyzed reductive amination
General Synthesis of Alkyl Amines via Borrowing Hydrogen and Reductive Amination
Ruthenium-Catalyzed Enantioselective Reductive Amination
Asymmetric Reductive Amination of Ketones
Aqueous reductive amination using a dendritic metal catalyst in a dialysis bag
Amination of alcohols by nucleophilic substitution or reductive amination
Efficient synthesis of amines : from reductive amination of aldehydes to hydroaminomethylation of olefins
The Synthesis of Primary Amines through Reductive Amination Employing an Iron Catalyst
Co‐Catalyzed Synthesis of Primary Amines via Reductive Amination employing Hydrogen under very mild Conditions
Co Catalyzed Synthesis of Primary Amines via Reductive Amination employing Hydrogen under very mild Conditions
Rhodium‐Catalysed Reductive Amination for the Synthesis of Tertiary Amines
General Synthesis of Alkyl Amines via Borrowing Hydrogen and Reductive Amination
Asymmetric synthesis of γ-branched amines via rhodium-catalyzed reductive amination
General Synthesis of Alkyl Amines via Borrowing Hydrogen and Reductive Amination
Ruthenium-Catalyzed Enantioselective Reductive Amination
Asymmetric Reductive Amination of Ketones
Aqueous reductive amination using a dendritic metal catalyst in a dialysis bag
Amination of alcohols by nucleophilic substitution or reductive amination