General Synthesis of Alkyl Amines via Borrowing Hydrogen and Reductive Amination

Abstract: Amines are a very important class of compounds and the selective synthesis of differently substituted primary, secondary and tertiary alkyl amines is challenging. Here we present the synthesis of primary, secondary, and tertiary alkyl amines from ammonia and alcohols, aldehydes, ketones and hydrogen by combining borrowing hydrogen or hydrogen autotransfer and reductive amination with hydrogen. The key is a nanostructured, bimetallic Co/Sc catalyst able to mediate both reactions or concepts efficiently. We observe a broad product scope, a very good functional group tolerance, upscaling is easily accomplished and our catalyst is reusable.

Location
Deutsche Nationalbibliothek Frankfurt am Main
Extent
Online-Ressource
Language
Englisch

Bibliographic citation
General Synthesis of Alkyl Amines via Borrowing Hydrogen and Reductive Amination ; day:21 ; month:11 ; year:2023 ; extent:9
Advanced synthesis & catalysis ; (21.11.2023) (gesamt 9)

Creator
Elfinger, Matthias
Bauer, Christof
Schmauch, Jörg
Moritz, Michael
Wichmann, Christoph
Papp, Christian
Kempe, Rhett

DOI
10.1002/adsc.202301179
URN
urn:nbn:de:101:1-2023112214194879499726
Rights
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
Last update
15.08.2025, 7:28 AM CEST

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