General Synthesis of Alkyl Amines via Borrowing Hydrogen and Reductive Amination
Abstract: Amines are a very important class of compounds and the selective synthesis of differently substituted primary, secondary and tertiary alkyl amines is challenging. Here we present the synthesis of primary, secondary, and tertiary alkyl amines from ammonia and alcohols, aldehydes, ketones and hydrogen by combining borrowing hydrogen or hydrogen autotransfer and reductive amination with hydrogen. The key is a nanostructured, bimetallic Co/Sc catalyst able to mediate both reactions or concepts efficiently. We observe a broad product scope, a very good functional group tolerance, upscaling is easily accomplished and our catalyst is reusable.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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General Synthesis of Alkyl Amines via Borrowing Hydrogen and Reductive Amination ; day:21 ; month:11 ; year:2023 ; extent:9
Advanced synthesis & catalysis ; (21.11.2023) (gesamt 9)
- Urheber
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Elfinger, Matthias
Bauer, Christof
Schmauch, Jörg
Moritz, Michael
Wichmann, Christoph
Papp, Christian
Kempe, Rhett
- DOI
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10.1002/adsc.202301179
- URN
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urn:nbn:de:101:1-2023112214194879499726
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:28 MESZ
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Beteiligte
- Elfinger, Matthias
- Bauer, Christof
- Schmauch, Jörg
- Moritz, Michael
- Wichmann, Christoph
- Papp, Christian
- Kempe, Rhett
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