Clinical on-site monitoring of ß-lactam antibiotics for a personalized antibiotherapy

Abstract: An appropriate antibiotherapy is crucial for the safety and recovery of patients. Depending on the clinical conditions of patients, the required dose to e ectively eradicate an infection may vary. An inadequate dosing not only reduces the e cacy of the antibiotic, but also promotes the emergence of antimicrobial resistances. Therefore, a personalized therapy is of great interest for improved patients’ outcome and will reduce in long-term the prevalence of multidrug-resistances. In this context, on-site monitoring of the antibiotic blood concentration is fundamental to facilitate an individual adjustment of the antibiotherapy. Herein, we present a bioinspired approach for the bedside monitoring of free accessible ß-lactam antibiotics, including penicillins (piperacillin) and cephalosporins (cefuroxime and cefazolin) in untreated plasma samples. The introduced system combines a disposable micro uidic chip with a naturally occurring penicillin-binding protein, resulting in a high-performance platform, capable of gauging very low antibiotic concentrations (less than 6 ng ml⁻¹) from only 1 μl of serum. The system’s applicability to a personalized antibiotherapy was successfully demonstrated by monitoring the pharmacokinetics of patients, treated with ß-lactam antibiotics, undergoing surgery

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch
• Notes: Scientific Reports. 7 (2017), 3127, DOI 10.1038/s41598-017-03338-z, issn: 2045-2322 ; cc_by http://creativecommons.org/licenses/by/4.0/deed.de cc

Classification and Topics

• Keyword: Individualisierte Medizin ; Antibiotikum ; Biosensor ; Elektrochemie ; Biopharmazie ; Pharmakodynamik ; Pharmakokinetik

Contributors, Places and Time

• Event: Veröffentlichung
• (where): Freiburg
• (who): Universität
• (when): 2017
• Creator: Bruch, Richard ; Chatelle, Claire ; Kling, André ; Rebmann, Balder ; Wirth, Steffen ; Schumann, Stefan ; Weber, Wilfried ; Dincer, Can ; Urban, Gerald A.
• Contributor: Albert-Ludwigs-Universität Freiburg. Institut für Mikrosystemtechnik ; Albert-Ludwigs-Universität Freiburg. Medizinische Fakultät ; Albert-Ludwigs-Universität Freiburg. Fakultät für Biologie ; Universitätsklinikum Freiburg ; Freiburger Material-Forschungszentrum ; Albert-Ludwigs-Universität Freiburg. Centre for Biological Signalling Studies ; Albert-Ludwigs-Universität Freiburg

Further information

• DOI: 10.1038/s41598-017-03338-z
• URN: urn:nbn:de:bsz:25-freidok-128179
• Rights: Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:39 AM CEST