Randomized cross-over evaluation of investigator gender on pain thresholds in healthy volunteers
Abstract: Background and aims: This randomized cross-over study in healthy volunteers was designed primarily to evaluate the potential impact of investigator gender on electrical pain threshold (EPT) and corresponding pain intensity levels, and secondly to evaluate potential differences in those interventions between female and male study participants.Methods: Forty adult volunteers (22 females) were included. An electrical stimulation device was used to determine EPT levels (in pain magnitude scores) in series of three in each study participant - once by a female, and once by a male investigator - according to a predefined cross-over design schedule. Corresponding levels of pain intensity were scored on a visual analog scale (VAS) slide ruler.Results: Study data was obtained and analysed in all participants. Significantly higher EPT levels were determined by the female investigator compared with the male investigator (median 22 (IQR 12-31) vs. 8 (6-10) pain magnitude scores; p <0.0001),...
Abstract: Hintergrund und Ziele: Diese präklinische randomisierte Cross-Over-Studie wurde entwickelt, um 1) einen möglichen Einfluss des Geschlechts der Untersucher auf die Schwellenwerte für elektrische Schmerzen (EPT) und entsprechende Schmerzintensität bei gesunden Freiwilligen zu bewerten, und 2) mögliche Unterschiede bei diesen Interventionen zwischen weiblichen und männlichen Studienteilnehmern zu bewerten.Methoden: Vierzig gesunde erwachsene Freiwillige (22 Frauen) wurden eingeschlossen. Mit einem elektrischen Stimulationsgerät wurden die EPT-Spiegel in Dreierreihen bei jedem Studienteilnehmer - einmal von einem weiblichen und einmal von einem männlichen Untersucher - gemäß einem vordefinierten Cross-Over-Entwurfsplan bestimmt. Entsprechende Niveaus der Schmerzintensität wurden auf einem VAS-Lineal bewertet.Ergebnisse: Studiendaten wurden bei allen Teilnehmern erhoben und analysiert. Im Vergleich zum männlichen Untersucher wurden von der weiblichen Untersucherin signifikant höhere...
- Weitere Titel
-
Randomisierte Cross-Over-Bewertung vom Geschlecht des Untersuchers auf die Schmerzschwelle bei gesunden Freiwilligen
- Standort
-
Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
-
Online-Ressource
- Sprache
-
Englisch
- Erschienen in
-
Randomized cross-over evaluation of investigator gender on pain thresholds in healthy volunteers ; volume:19 ; day:29 ; month:11 ; year:2021
GMS german medical science / Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften ; 19 (29.11.2021)
- Klassifikation
-
Medizin, Gesundheit
- Urheber
-
Sellgren, Engskov Anna
Lejbman, Ilja
Åkeson, Jonas
- DOI
-
10.3205/000301
- URN
-
urn:nbn:de:0183-0003016
- Rechteinformation
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
-
15.08.2025, 07:26 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Sellgren, Engskov Anna
- Lejbman, Ilja
- Åkeson, Jonas
Ähnliche Objekte (12)
Morphine interaction with prasugrel: a double-blind, cross-over trial in healthy volunteers
The effect of dipyridamole on the pharmacokinetics of metformin: a randomized crossover study in healthy volunteers
Detection of critical cerebral desaturation thresholds by three regional oximeters during hypoxia: a pilot study in healthy volunteers
The Effects of Clarithromycin on the Pharmacokinetics of Apixaban in Healthy Volunteers: A Single-Sequence Crossover Study
Effect of chamomile intake on blood coagulation tests in healthy volunteers: a randomized, placebo-controlled, crossover trial
Safety and tolerability of virucidal hand rubs: a randomized, double-blind, cross-over trial with healthy volunteers
Systemic Ropivacaine Diminishes Pain Sensitization Processes: A Randomized, Double-Blinded, Placebo-Controlled, Crossover Study in Healthy Volunteers
A crossover randomized comparative study of zofenopril and ramipril on cough reflex and airway inflammation in healthy volunteers
Efficacy of ethanol-based hand foams using clinically relevant amounts: a cross-over controlled study among healthy volunteers
Efficacy of Moringa oleifera leaf powder as a hand- washing product: a crossover controlled study among healthy volunteers
Randomised, crossover clinical trial, in healthy volunteers, to compare the systemic availability of two topical intranasal budesonide formulations
Acute cardiovascular effects of controlled exposure to dilute Petrodiesel and biodiesel exhaust in healthy volunteers: a crossover study
Morphine interaction with prasugrel: a double-blind, cross-over trial in healthy volunteers
The effect of dipyridamole on the pharmacokinetics of metformin: a randomized crossover study in healthy volunteers
Detection of critical cerebral desaturation thresholds by three regional oximeters during hypoxia: a pilot study in healthy volunteers
The Effects of Clarithromycin on the Pharmacokinetics of Apixaban in Healthy Volunteers: A Single-Sequence Crossover Study
Effect of chamomile intake on blood coagulation tests in healthy volunteers: a randomized, placebo-controlled, crossover trial
Safety and tolerability of virucidal hand rubs: a randomized, double-blind, cross-over trial with healthy volunteers
Systemic Ropivacaine Diminishes Pain Sensitization Processes: A Randomized, Double-Blinded, Placebo-Controlled, Crossover Study in Healthy Volunteers
A crossover randomized comparative study of zofenopril and ramipril on cough reflex and airway inflammation in healthy volunteers
Efficacy of ethanol-based hand foams using clinically relevant amounts: a cross-over controlled study among healthy volunteers
Efficacy of Moringa oleifera leaf powder as a hand- washing product: a crossover controlled study among healthy volunteers
Randomised, crossover clinical trial, in healthy volunteers, to compare the systemic availability of two topical intranasal budesonide formulations
Acute cardiovascular effects of controlled exposure to dilute Petrodiesel and biodiesel exhaust in healthy volunteers: a crossover study
Morphine interaction with prasugrel: a double-blind, cross-over trial in healthy volunteers
The effect of dipyridamole on the pharmacokinetics of metformin: a randomized crossover study in healthy volunteers
Detection of critical cerebral desaturation thresholds by three regional oximeters during hypoxia: a pilot study in healthy volunteers
The Effects of Clarithromycin on the Pharmacokinetics of Apixaban in Healthy Volunteers: A Single-Sequence Crossover Study
Effect of chamomile intake on blood coagulation tests in healthy volunteers: a randomized, placebo-controlled, crossover trial
Safety and tolerability of virucidal hand rubs: a randomized, double-blind, cross-over trial with healthy volunteers
Systemic Ropivacaine Diminishes Pain Sensitization Processes: A Randomized, Double-Blinded, Placebo-Controlled, Crossover Study in Healthy Volunteers
A crossover randomized comparative study of zofenopril and ramipril on cough reflex and airway inflammation in healthy volunteers
Efficacy of ethanol-based hand foams using clinically relevant amounts: a cross-over controlled study among healthy volunteers
Efficacy of Moringa oleifera leaf powder as a hand- washing product: a crossover controlled study among healthy volunteers
Randomised, crossover clinical trial, in healthy volunteers, to compare the systemic availability of two topical intranasal budesonide formulations